COLOSTRUM

Also known as:  Bovine Colostrum;  Cow Colostrum;  Foremilk

Description

Bovine Colostrum is a thin, white, opalescent fluid (a Dairy Product) obtained from Cows (Bovine) that is the first Milk secreted at the termination of Pregnancy.

Bovine Colostrum is used as a therapeutic agent because its constituents are almost identical to those present in human Colostrum.

Health Benefits of Colostrum

Cells

Colostrum may stimulate Growth (due to Growth Factors present in Colostrum). 

Digestive System

ùColostrum may be an effective treatment for Diarrhea (due to its ability to improve the health of the Intestinal Wall). 

ùColostrum may help to prevent Duodenal Ulcers (by inhibiting the Helicobacter pylori Bacteria that causes many cases of Duodenal Ulcers).  references

ùColostrum may help to prevent Gastritis (by inhibiting the Helicobacter pylori Bacteria that causes many cases of Duodenal Ulcers). 

ùColostrum may help to prevent Gastroenteritis. 

ùColostrum may help to prevent and treat Intestinal Permeability. 

ùColostrum may enhance the health of the Intestinal Wall (primarily due to the Lactoferrin content of Colostrum). 

ùColostrum may help to protect the Stomach from the toxic effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDS).

ùColostrum may alleviate Ulcerative Colitis. 

Immune System

ùColostrum contains Antibodies and may enhance the endogenous production of Antibodies (the purpose of human Colostrum is to provide newborn infants with Antibodies that confer immunity).  C

ùColostrum may be a valuable treatment for many Bacterial & Viral Diseases (infections): 

ùColostrum may treat and prevent Diarrhea in Acquired Immune Deficiency Syndrome (AIDS) patients.

ùColostrum may help to prevent Upper Respiratory Tract Infections. 

ùColostrum (Bovine Colostrum) may help to prevent Cryptosporidium-induced Diarrhea (Cryptosporidiosis).        

ùColostrum may inhibit many types of Detrimental Bacteria  including:

–        Campylobacter jejuni 

–        Clostridium difficile 

–        Escherichia coli 

–        Helicobacter pylori  (Colostrum may inhibit the ability of Helicobacter pylori to bind to Receptors on the Intestinal surface)

–        Yersinia enterocolitica 

Metabolism

ùColostrum may improve Athletic Performance. 

ùMusculoskeletal System

ùColostrum may enhance Muscle Growth (due to Growth Factors including IGF-1 in Colostrum). 

Nervous System

ùCololstrum may improve the condition of Alzheimer’s Disease patients (due to the Proline Rich Polypeptide content of Colostrum). 

Respiratory System

ùColostrum may help to prevent Upper Respiratory Tract Infections.

ùColostrum is considered to be a useful treatment for (recurrent) Sinusitis. 

Skin

Colostrum (applied topically) is claimed (by its manufacturers) to “nourish” the Skin and may help to prevent Wrinkles (due to the Epidermal Growth Factor (EGF) content of Colostrum) (however there is little scientific basis for this claim).  references

ùColostrum may accelerate the healing of Wounds (due to the Growth Factors content of Colostrum). 

Colostrum may Enhance the Function of these Substances

ùGrowth Factors

ùColostrum may increase the body’s levels of Insulin-like Growth Factor-1 (IGF-1) (due to the IGF-1 content of Colostrum).  references

Immune System Chemicals

ùColostrum may increase the body’s production of Interferon Gamma (due to the Proline Rich Polypeptide content of Colostrum). 

ùColostrum may Inhibit the Toxic Effects of these Substances Pharmaceutical Drugs Colostrum may help to protect the Stomach and Intestines from the toxic effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDS).

Bovine Colostrum Contains these Substances

Amino Acids:                Proline

Carbohydrates:             Lactose

Cytokines:           Interleukin 1

Interleukin 6

ùEnzymes:                   Trypsin   Lysozyme

ùGrowth Factors:                 Epidermal Growth Factor (EGF) Insulin-like Growth Factor-1 (IGF-1) Insulin-like Growth Factor-2 (IGF-2)

Platelet-Derived Growth Factor (PDGF) Transforming Growth Factor-beta (TGF-b)

ùPeptides:          Carnitine

Proline Rich Polypeptide (PRP)

ùProteins: 63% Glycoproteins

IgA

IgE

IgG

IgM

Lactoferrin

ù      The IGF-1 present in Bovine Colostrum is identical in molecular structure to that of human IGF-1 except for a 26 Amino Acid “flag sequence” on the front of Bovine IGF-1 (when Bovine Colostrum IGF-1 is cleaved by Digestive Enzymes in the Stomach, it is converted to a molecule that is identical to human IGF-1).

ù      It was once doubted that the IGF-1 of Bovine Colostrum could be effectively digested and incorporated into the bloodstream for use by the human body as a fully-functioning Hormone.  However, recent research has demonstrated that Bovine Colostrum increases endogenous IGF-1 levels, indicating that the IGF-1 content of Bovine Colostrum is effectively absorbed into the human body.

Dosage Recommendations 

ùThe general therapeutic dosage of Colostrum is 700 – 9,000 mg per day.

ùThe dosage of Colostrum used by athletes for improving performance is 20 – 60 grams per day.

Colostrum Compared to Cow’s Milk

ùColostrum does NOT contain the Antigens that are present in Cow’s Milk.

Commercial Availability of Bovine Colostrum Supplements

Oral Supplements

Bovine Colustrum supplements are available from health food stores and mail order supplement companies in the form of:

–        powder (containing 1,250 mg Colostrum per teaspoon).

–        powder standardized to contain 17.08% Immunoglobulins.

–        powder standardized to contain 20% IgG

–        250 mg capsules

–        350 mg capsules

–        475 mg capsules standardized to contain 25% IgG

–        475 mg capsules standardized to contain 40% IgG

–        480 mg capsules

–        500 mg tablets

–        650 mg tablets

–        1,000 mg tablets standardized to contain 25% Immunoglobulins.

–        liquid Bovine Colostrum (concentrated to a ratio of 4:1)

Topical Products

Bovine Colostrum is the active ingredient in some topically-applied Skin Creams.

Manufacturing Methods

Bovine Colostrum supplements that are processed using lypholization (freeze-dried vacuum process) using no heat and claimed to be superior to Bovine Colostrum supplements prepared using spray drying (which uses heat and may reduce the effectiveness of or destroy the constituents of Bovine Colostrum).

Standardization

ùSome Bovine Colostrum supplements are standardized to contain up to 25% Immunoglobulins.

COLOSTRUM

Also known as:  Bovine Colostrum;  Cow Colostrum;  Foremilk

Description

Bovine Colostrum is a thin, white, opalescent fluid (a Dairy Product) obtained from Cows (Bovine) that is the first Milk secreted at the termination of Pregnancy.

Bovine Colostrum is used as a therapeutic agent because its constituents are almost identical to those present in human Colostrum.

Health Benefits of Colostrum

Cells

Colostrum may stimulate Growth (due to Growth Factors present in Colostrum). 

Digestive System

ùColostrum may be an effective treatment for Diarrhea (due to its ability to improve the health of the Intestinal Wall). 

ùColostrum may help to prevent Duodenal Ulcers (by inhibiting the Helicobacter pylori Bacteria that causes many cases of Duodenal Ulcers).  references

ùColostrum may help to prevent Gastritis (by inhibiting the Helicobacter pylori Bacteria that causes many cases of Duodenal Ulcers). 

ùColostrum may help to prevent Gastroenteritis. 

ùColostrum may help to prevent and treat Intestinal Permeability. 

ùColostrum may enhance the health of the Intestinal Wall (primarily due to the Lactoferrin content of Colostrum). 

ùColostrum may help to protect the Stomach from the toxic effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDS).

ùColostrum may alleviate Ulcerative Colitis. 

Immune System

ùColostrum contains Antibodies and may enhance the endogenous production of Antibodies (the purpose of human Colostrum is to provide newborn infants with Antibodies that confer immunity).  C

ùColostrum may be a valuable treatment for many Bacterial & Viral Diseases (infections): 

ùColostrum may treat and prevent Diarrhea in Acquired Immune Deficiency Syndrome (AIDS) patients.

ùColostrum may help to prevent Upper Respiratory Tract Infections. 

ùColostrum (Bovine Colostrum) may help to prevent Cryptosporidium-induced Diarrhea (Cryptosporidiosis).        

ùColostrum may inhibit many types of Detrimental Bacteria  including:

–        Campylobacter jejuni 

–        Clostridium difficile 

–        Escherichia coli 

–        Helicobacter pylori  (Colostrum may inhibit the ability of Helicobacter pylori to bind to Receptors on the Intestinal surface)

–        Yersinia enterocolitica 

Metabolism

ùColostrum may improve Athletic Performance. 

ùMusculoskeletal System

ùColostrum may enhance Muscle Growth (due to Growth Factors including IGF-1 in Colostrum). 

Nervous System

ùCololstrum may improve the condition of Alzheimer’s Disease patients (due to the Proline Rich Polypeptide content of Colostrum). 

Respiratory System

ùColostrum may help to prevent Upper Respiratory Tract Infections.

ùColostrum is considered to be a useful treatment for (recurrent) Sinusitis. 

Skin

Colostrum (applied topically) is claimed (by its manufacturers) to “nourish” the Skin and may help to prevent Wrinkles (due to the Epidermal Growth Factor (EGF) content of Colostrum) (however there is little scientific basis for this claim).  references

ùColostrum may accelerate the healing of Wounds (due to the Growth Factors content of Colostrum). 

Colostrum may Enhance the Function of these Substances

ùGrowth Factors

ùColostrum may increase the body’s levels of Insulin-like Growth Factor-1 (IGF-1) (due to the IGF-1 content of Colostrum).  references

Immune System Chemicals

ùColostrum may increase the body’s production of Interferon Gamma (due to the Proline Rich Polypeptide content of Colostrum). 

ùColostrum may Inhibit the Toxic Effects of these Substances Pharmaceutical Drugs Colostrum may help to protect the Stomach and Intestines from the toxic effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDS).

Bovine Colostrum Contains these Substances

Amino Acids:                Proline

Carbohydrates:             Lactose

Cytokines:           Interleukin 1

Interleukin 6

ùEnzymes:                   Trypsin   Lysozyme

ùGrowth Factors:                 Epidermal Growth Factor (EGF) Insulin-like Growth Factor-1 (IGF-1) Insulin-like Growth Factor-2 (IGF-2)

Platelet-Derived Growth Factor (PDGF) Transforming Growth Factor-beta (TGF-b)

ùPeptides:          Carnitine

Proline Rich Polypeptide (PRP)

ùProteins: 63% Glycoproteins

IgA

IgE

IgG

IgM

Lactoferrin

ù      The IGF-1 present in Bovine Colostrum is identical in molecular structure to that of human IGF-1 except for a 26 Amino Acid “flag sequence” on the front of Bovine IGF-1 (when Bovine Colostrum IGF-1 is cleaved by Digestive Enzymes in the Stomach, it is converted to a molecule that is identical to human IGF-1).

ù      It was once doubted that the IGF-1 of Bovine Colostrum could be effectively digested and incorporated into the bloodstream for use by the human body as a fully-functioning Hormone.  However, recent research has demonstrated that Bovine Colostrum increases endogenous IGF-1 levels, indicating that the IGF-1 content of Bovine Colostrum is effectively absorbed into the human body.

Dosage Recommendations 

ùThe general therapeutic dosage of Colostrum is 700 – 9,000 mg per day.

ùThe dosage of Colostrum used by athletes for improving performance is 20 – 60 grams per day.

Colostrum Compared to Cow’s Milk

ùColostrum does NOT contain the Antigens that are present in Cow’s Milk.

Commercial Availability of Bovine Colostrum Supplements

Oral Supplements

Bovine Colustrum supplements are available from health food stores and mail order supplement companies in the form of:

–        powder (containing 1,250 mg Colostrum per teaspoon).

–        powder standardized to contain 17.08% Immunoglobulins.

–        powder standardized to contain 20% IgG

–        250 mg capsules

–        350 mg capsules

–        475 mg capsules standardized to contain 25% IgG

–        475 mg capsules standardized to contain 40% IgG

–        480 mg capsules

–        500 mg tablets

–        650 mg tablets

–        1,000 mg tablets standardized to contain 25% Immunoglobulins.

–        liquid Bovine Colostrum (concentrated to a ratio of 4:1)

Topical Products

Bovine Colostrum is the active ingredient in some topically-applied Skin Creams.

Manufacturing Methods

Bovine Colostrum supplements that are processed using lypholization (freeze-dried vacuum process) using no heat and claimed to be superior to Bovine Colostrum supplements prepared using spray drying (which uses heat and may reduce the effectiveness of or destroy the constituents of Bovine Colostrum).

Standardization

ùSome Bovine Colostrum supplements are standardized to contain up to 25% Immunoglobulins.