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Show of the Week January 3 2011

 

Health Benefits of Parsley

 

US threatened – More Like the GMO or GE companies – ‘retaliation’ to bully EU into accepting biotech crops, cable shows

 

Coffee and liver diseases

 

Pollutants in boys’ blood tied to lower growth

 

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US threatened – More Like the GMO or GE companies – ‘retaliation’ to bully EU into accepting biotech crops, cable shows

Reacting to a French pledge to represent the “common interest” in considering biotech foods, a former US ambassador recommended publishing a “retaliation list” of European locations where genetically modified organisms (GMOs) were being grown in hopes that activists would destroy them and “cause some pain” for officials, a leaked diplomatic cable shows.–In a confidential communication dated Dec. 14, 2007 and released by WikiLeaks on Sunday, then-US Ambassador to France Craig Roberts Stapleton recommended creating the list if France and the EU continued to ban biotech seeds.–“Mission Paris recommends that that the [United States government] reinforce our negotiating position with the EU on agricultural biotechnology by publishing a retaliation list when the extend ‘Reasonable Time Period’ expires,” Stapleton wrote. “Europe is moving backwards not forwards on this issue with France playing a leading role, along with Austria, Italy and even the [European] Commission.”
Stapelton added that the US should create a list “that causes some pain across the EU, since this is a collective responsibility, but that also focuses in part on the worst culprits.” –He continued: “The list should be measured rather than vicious and must be sustainable over the long term, since we should not expect an early victory.” The former US official added that France’s “High Authority” on agricultural biotech was particularly offensive because it sought to “roll back established science-based decision making.” He added that a bill considered by the French National Assembly should be rebuked by the publication “of a registry identifying the cultivation of GMOs at the parcel levels” … “given the propensity for activists to destroy GMO crops in the field.”–The document would appear to expose a high-ranking US official advocating a selective leak of otherwise confidential information to achieve a European political objective on behalf of US private industry. —The law that was considered in France would have made farmers and biotech firms liable for pollen drift of their modified crops — a move that “could make any biotech planting impossible in practical terms,[U1]” the Stapleton wrote.
It was essentially the same principle the US employs for environmental pollution: the polluter must pay. GMO firms, however, are given exception to those regulations in North America.
The spread of modified genes into the wild is of particular concern to critics of biotech food crops, who cite studies linking GM seeds to organ damage and infertility in animals. Most Monsanto seeds are modified to resist pesticides such as Roundup, which has been shown to cause cancer and genetic mutations in humans. It is still unclear whether genetically modified foods pose health risks, but they have been adopted in soaring quantities in the United States. “Soybeans and cotton genetically engineered with herbicide-tolerant traits have been the most widely and rapidly adopted GE crops in the U.S., followed by insect-resistant cotton and corn,” according to the US Department of Agriculture (USDA).

 

Researchers at the University of Arkansas found in August that canola, a modified rapeseed used mainly for oil, had managed to sustain itself in the wilds of North Dakota. Up to 80 percent of the plants they tested had genes that were modified to resist herbicide. It was the first time modified crops had been discovered growing in the wild[U2], the BBC noted.
Monsanto’s genetically modified corn, currently banned across the EU, was also found growing in Ireland, the Irish Department of Agriculture said. –Stapleton was appointed Ambassador to France in 2005 by President George W. Bush. His wife is a cousin of President George H.W. Bush. Stapelton was replaced as ambassador in July 2009, when President Barack Obama named Charles Rivkin to the post.
Europe continues biotech resistance
It’s not clear from the release if the US went ahead with its plan for the “retaliation list,” but Stapelton was certainly right on whether the US should expect an early victory in European public opinion. In December, more than one million Europeans signed a petition demanding the EU halt the approval of new genetically modified crops. The petition was later dismissed by the EU Commission on procedural grounds.–In the last 12 years only two organisms have been licensed for seeding across Europe, and one of them was a potato that triggered the recent mass petition against the crops. The number one multinational biotech firm in the world, Monsanto, isn’t happy about that.-But like other US business interests, Monsanto hasn’t been sitting around whining about policy backlash foreign or domestic. The Nation’s Jeremy Scahill revealed in September that the world’s top producer of genetically modified seeds hired US security contractor Blackwater to “infiltrate activist groups organizing against the multinational biotech firm.” The leaked cable makes no mention of Blackwater mercenaries operating in Europe. Other cables released in recent days showed that, behind the scenes, Spain has been a key ally of the US in defending genetically modified crops.
Spanish Secretary of State and Deputy Minister Josep Puxeu contacted US officials to ask for support after his country came under pressure to ban their Monsanto-developed MON810 corn crop, a cable revealed. “He asked that the USG maintain pressure on Brussels to keep agricultural biotechnology an option for Member States and requested that the USG work together with Spain in this endeavor.” Another cable sent to the Vatican on Nov. 19, 2009 indicated that Pope Benedict XVI also supports genetically modified crops, but will not admit it in public. “Vatican officials remain largely supportive of genetically modified crops as a vehicle for protecting the environment while feeding the hungry, but — at least for now — are unwilling to challenge bishops who disagree,” it explained.

 

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Coffee and liver diseases.

Fitoterapia. 2010 Jul;81(5):297-305-Authors: Muriel P, Arauz J

Coffee consumption is worldwide spread with few side effects. Interestingly, coffee intake has been inversely related to the serum enzyme activities gamma-glutamyltransferase, and alanine aminotransferase in studies performed in various countries. In addition, epidemiological results, taken together, indicate that coffee consumption is inversely related with hepatic cirrhosis; however, they cannot demonstrate a causative role of coffee with prevention of liver injury. Animal models and cell culture studies indicate that kahweol, diterpenes and cafestol (some coffee compounds) can function as blocking agents by modulating multiple enzymes involved in carcinogenic detoxification; these molecules also alter the xenotoxic metabolism by inducing the enzymes glutathione-S-transferase and inhibiting N-acetyltransferase. Drinking coffee has been associated with reduced risk of hepatic injury and cirrhosis, a major pathogenic step in the process of hepatocarcinogenesis, thus, the benefit that produces coffee consumption on hepatic cancer may be attributed to its inverse relation with cirrhosis, although allowance for clinical history of cirrhosis did not completely account for the inverse association. Therefore, it seems to be a continuum of the beneficial effect of coffee consumption on liver enzymes, cirrhosis and hepatocellular carcinoma. At present, it seems reasonable to propose experiments with animal models of liver damage and to test the effect of coffee, and/or isolated compounds of this beverage, not only to evaluate the possible causative role of coffee but also its action mechanism. Clinical prospective double blind studies are also needed.– PMID: 19825397 [PubMed – indexed for MEDLINE]

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Pollutants in boys’ blood tied to lower growth

NEW YORK (Reuters Health) – Russian boys exposed to unusually high levels of environmental pollutants are smaller than their peers, a new study reports.-After following nearly 500 boys for three years, an international group of researchers found that those with the highest levels of polychlorinated biphenyls (PCBs) in their blood were nearly three centimeters (more than an inch) shorter than boys from the same region with the lowest amount of PCBs in their bodies. Boys with the highest exposures also averaged two points lower in body mass index (BMI), a measure of weight relative to height.–The authors found a similar pattern in boys with the highest exposure to the pollutant dioxin.–“You’re always a little surprised to see such a dramatic effect,” study author Jane Burns of the Harvard School of Public Health told Reuters Health, but the findings are “consistent” with some other research about the effect of these chemicals.–Burns explained that the boys included in the study have much higher exposures to these pollutants than the general U.S. population, likely a result of their proximity to a chemical plant that generated dioxin as a byproduct. But a small number of people in the U.S. and other developed countries live in regions with exposures that match – or even exceed – those seen here, she added.—PCBs were once used in everything from appliances and fluorescent lighting to insulation and insecticides. While the chemicals were banned in the 1970s as potential health hazards, they remain a public-health concern because they linger in the environment and accumulate in the fat of fish, mammals and birds.–Research has linked PCBs to an elevated risk of cancer, type 2 diabetes and other ailments. A study of children in Taiwan also found that those exposed in utero to PCBs from contaminated cooking oil were shorter than their peers. Dioxins are toxic substances formed by burning — for example in waste incinerators or forest fires — and in some industrial processes. Airborne dioxins are deposited onto plants, soils and water, and they enter the food chain when ingested by livestock and fish. Dioxin exposure has been shown to lead to both higher cancer rates and changes in birth rates resulting in more female babies and fewer males.—To further investigate the impact of high exposures to PCBs and dioxins on growth, Burns and her colleagues took blood samples from 499 boys ages 8 and 9 living in Chapaevsk, Russia, an area known to be highly contaminated.–Indeed, the highest levels of PCBs and dioxins in the boys’ blood far exceeded those found in the average U.S. population, Burns noted.—Prenatal exposure to PCBs, but not dioxins, has been linked to low birth weight. And along with differences in the prepubescent boys’ height and weight, the authors found that those with the highest blood levels of PCBs were growing significantly more slowly than boys with the least exposure – by about 0.2 centimeters a year over the three-year study period.–The findings appear in the journal Pediatrics.–It’s not entirely clear why PCBs or dioxins might affect growth, Burns said in an interview. “We’re not really sure of what the mechanisms are.” Research suggests dioxins interfere with genes that regulate normal development, while PCBs disrupt the regulation of thyroid hormones, which could impact growth.

SOURCE: http://link.reuters.com/vab24r Pediatrics, online December 27, 2010.

 

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[U1]This is what should have been here in Canada and The USA–instead we have given the Agro Corporates free and and clear access to dump-contaminate and cause chaos and havoc with creation–if this was enforced then Monsanto would have been the ones who would have lost the farms–Not the farmers they stripped and stole there lands through litigations and unjust rulings making the farmer at fault when in reality the Agro Companies like this would have been the ones to Pay—this kind of Agro business should have never been allowed to even begin to flourish or released–The Supreme court ruling that favoured this should not have transpired

[U2]DING DING DING!!!! DANGER DANGER —this is all we need to have our healthy foods mixed with this Genetic Abomination

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Show of the Week January 7 2011

USDA Certified Organics Dirty Little Secret- Neotame
The Vermont Resolution for Food Sovereignty

NOTICE!-DO NOT DISCARD

Multi Studies and Solutions (1) Isoquercitrin (2) Uptake of Antioxidants in kidneys and liver and heart (3) Minimizing radiation exposure to intestine (4) Wolfberry or Goji Berry on intestinal Cancers (5) Probiotic-Prebiotic and Oils protection

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A) USDA Certified Organics Dirty Little Secret- Neotame

 

Just when we thought that buying “Organic” was safe, we run headlong into the deliberate poisoning of our organic food supply by the FDA [U1] in collusion with none other than the folks who brought us Aspartame. NutraSweet, a former Monsanto asset, has developed a new and improved version of this neurotoxin called Neotame. —Neotame has similar structure to aspartame — except that, from it’s structure, appears to be even more toxic than aspartame. This potential increase in toxicity will make up for the fact that less will be used in diet drinks. Like aspartame, some of the concerns include gradual neurotoxic and immunotoxic damage from the combination of the formaldehyde metabolite (which is toxic at extremely low doses) and the excitotoxic amino acid. (Holisticmed.com) –But surely, this product would be labeled! NOT SO!!! For this little gem, no labeling required. And it is even included in USDA Certified Organic food. —The food labeling requirements required for aspartame have now been dropped for Neotame, and no one is clear why this was allowed to happen. Neotame has been ruled acceptable, and without being included on the list of ingredients, for:

USDA Certified Organic food items.
Certified Kosher products with the official letter k inside the circle on labels. (Janet Hull)
Let me make this perfectly clear. Neotame does not have to be included in ANY list of ingredients! So, if you buy processed food, whether USDA Certified Organic or not, that food most likely will contain Neotame because it is cost-effective, and since no one knows it is there, there is no public backlash similar to what is happening with Aspartame. A win/win situation! but that’s not all. Just love chowing down on that delicious steak? Well, that cow most likely will have been fed with feed containing…..you guessed it…..Neotame! A product called “Sweetos,” which is actually composed of Neotame, is being substituted for molasses in animal feed. —“Sweetos is an economical substitute for molasses. Sweetos guarantees the masking of unpleasant tastes and odor and improves the palatability of feed. This product will be economical for farmers and manufacturers of cattle feed. It can also be used in mineral mixture,” said Craig Petray, CEO, The NutraSweet Company, a division of Searle, which is a part of Monsanto. (Bungalow Bill)—- Why would we feed animals food that is so distasteful that we would have to mask the unpleasantness with an artificial sweetener? Most animals will not eat spoiled, rancid feed[U2] . They know by the smell that it is not good. Enter Sweetos (Neotame). Just cover up the unpleasant tastes and odors, and you can feed them anything you want to, courtesy of the oh, so considerate folks at Monsanto and company. But of course, Monsanto is no longer associated with NutraSweet. In the time-honored tradition of covering its assets, Monsanto has a proven track record of spinning off controversial portions of its company that generate too much scrutiny, such as it did with the Solutia solution.

 

Says the Farm Industry News, “Monsanto, which has long resided in the crosshairs of public scorn and scrutiny, appears to have dodged at least one bullet by spinning off its industrial chemical business into a separate entity called Solutia a couple of years ago. Solutia has since been hammered by lawsuits regarding PCB contamination from what were once called Monsanto chemical plants in Alabama and other states” (Source Watch) –So what is the solution to this problem? Buy Local Chemical FREE food, know your local farmer, and don’t buy processed foods whether they are labeled “Organic” or not. This requires a drastic change in lifestyle that most will not want to make. For those who choose to ride the wheel of chance by succumbing to this genocidal adulteration of our food supply by those who stand to profit from our sickness and early demise, my only comment is….it is your choice. But for those of us who have decided to fight this battle one bite at a time by hitting these GLOBALIST in the pocketbook where it hurts

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MOST LIKELY TO SECEDE:
The Vermont Resolution for Food Sovereignty

Time to get serious about Food Sovereignty.

WHEREAS All people are endowed by their Creator with certain inalienable rights, and among these are life, liberty and the pursuit of happiness; and WHEREAS Food is human sustenance and is the fundamental prerequisite to life; and WHEREAS The basis of human sustenance rests on the ability of all people to save seed, grow, process, consume and exchange food and farm products; and WHEREAS We the People of Vermont, have an obligation to protect these rights as is the Common and Natural Law; and in recognition of the State’s proud agricultural heritage; and the necessity of agricultural, ecological and economic diversity and sustainability to a free and healthy Society;
THEREFORE, Be it resolved, that We The People, stand on our rights under the 10th Amendment to the US Constitution and reject such Federal decrees, statutes, regulations or corporate practices that threaten our basic human right to save seed, grow, process, consume and exchange food and farm products within the State of Vermont; and, Be it further resolved, that We The People, shall resist any and all infringements upon these rights, from whatever sources that are contrary to the rights of the People of the State of Vermont

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NOTICE–DO NOT DISCARD

 

 

ü You should have a packet that looks like this from Senator Johnson which was hand carried by her two weeks ago.

 

ü A number of us helped distribute her letter to you because we represent hundreds of your constituents who are aware of a critical issue going on outlined in Senator Johnson’s letter.

 

ü We believe it’s imperative we take an active role in our local government since Arizona is being sanctioned in the billions at the end of this month by the EPA for what we believe is based on erroneous statistics. A letter will be delivered to you in a few days giving proof of this statement.

 

ü Additionally, EPA claims Arizona falls into the “Extreme Pollution Level” category. Interestingly, there are 11 other states within this same category, yet Arizona is the ONLY state being sanctioned!

 

ü Also interestingly, every registered vehicle in Arizona MUST meet EPA’s Vehicle Emissions Standards. Arizona motorists spend millions annually for this requirement. Has something failed in this process?

 

ü The Arizona Republic (9/4/10) states, “The particles, about one-seventh the size of a human hair, can invade the lungs and blood stream, aggravate asthma and other breathing problems, and can cause respiratory and heart ailments especially among children.”

 

ü These symptoms are exactly the result of a Geo-Engineering Program that has been going on in Arizona and globally, as portrayed in the documentary, “What in the World Are They Spraying” DVD in your packet.

 

ü Essentially, Arizona should NOT be financially burdened more than it already is for an unwarranted claim; illness described in EPA’s “Particulate Matter” description does NOT come from our road dust; and, Arizona should NOT be singled out for sanctions in the billions.

 

ü Since this Geo-Engineering Program is now being openly discussed to be legalized and outlines toxic heavy metals to be sprayed over humans . . our concerns cannot be passed on as a conspiracy theory! This MUST be addressed. We are counting on each and every one of you to take action. You will receive a follow-up letter in a few days. Thank you for your time.

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1) Inhibition of influenza virus replication by plant-derived isoquercetin.

Antiviral Res. 2010 Nov;88(2):227-35

Authors: Kim Y, Narayanan S, Chang KO

Influenza virus infects the respiratory system of human and animals causing mild to severe illness which could lead to death. Although vaccines are available, there is still a great need for influenza antiviral drugs to reduce disease progression and virus transmission. Currently two classes (M2 channel blockers and neuraminidase inhibitors) of FDA-approved influenza antiviral drugs are available, but there are great concerns of emergence of viral resistance. Therefore, timely development of new antiviral drugs against influenza viruses is crucial. Plant-derived polyphenols have been studied for antioxidant activity, anti-carcinogenic, and cardio- and neuroprotective actions. Recently, some polyphenols, such as resveratrol and epigallocatechin gallate, showed significant anti-influenza activity in vitro and/or in vivo. Therefore we investigated selected polyphenols for their antiviral activity against influenza A and B viruses. Among the polyphenols we tested, isoquercetin inhibited the replication of both influenza A and B viruses at the lowest effective concentration. In a double treatment of isoquercetin and amantadine, synergistic effects were observed on the reduction of viral replication in vitro. The serial passages of virus in the presence of isoquercetin did not lead to the emergence of resistant virus, and the addition of isoquercetin to amantadine or oseltamivir treatment suppressed the emergence of amantadine- or oseltamivir-resistant virus. In a mouse model of influenza virus infection, isoquercetin administered intraperitoneally to mice inoculated with human influenza A virus significantly decreased the virus titers and pathological changes in the lung. Our results suggest that isoquercetin may have the potential to be developed as a therapeutic agent for the treatment of influenza virus infection and for the suppression of resistance in combination therapy with existing drugs.– PMID: 20826184 [PubMed – indexed for MEDLINE]

ICan be found in Apples-Cherries- Onion- Bay leaf- Black Tea-Sweet Basil- AllSpice-Black Pepper-Apricot-Black Currant-White Willow-Elderberry—-these can as well be combined for instance you can combine apple and onion in a apple/onion sauce by blending the 2 together ( 2 apples to one onion (red onion has similar polyphenols that of red wine)–you can combo elderberry in an alcohol or honey mix by adding 1/4 cup of elderberry with 1 oz of brandy and 1/2 cup of honey -blend til fused smooth ( about 7 minutes at high speed ) or just use 1/4 cup of elderberry and 1/2 cup-3/4 cup of brandy or alcohol that is clear again blend for 10 minutes at high speed and then pour into a glass bottle-you can mix allspice with pepper when garnishing your foods in light doses when combined–you can combo elderberry and currant in a honey jam by adding equal parts of the currant to the elderberry and then double the volume of honey and blend-while blending add allspice to this about 1/2 tsp and then blend til smooth–these are some examples

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2) A dietary supplement containing multiple phytochemicals and vitamins elevates hepatorenal and cardiac antioxidant enzymes in the absence of significant serum chemistry and genomic changes.

Oxid Med Cell Longev. 2010 Mar-Apr;3(2):129-44

Authors: Bulku E, Zinkovsky D, Patel P, Javia V, Lahoti T, Khodos I, Stohs SJ, Ray SD

A novel dietary supplement composed of three well-known phytochemicals, namely, Salvia officinalis (sage) extract, Camellia sinensis (oolong tea) extract, and Paullinia cupana (guarana) extract, and two prominent vitamins (thiamine and niacin) was designed to provide nutritional support by enhancing metabolism and maintaining healthy weight and energy. The present study evaluated the safety of this dietary supplement (STG; S=sage; T=tea; G=guarana) and assessed changes in target organ antioxidant enzymes (liver, kidneys and heart), serum chemistry profiles and organ histopathology in Fisher 344 rats. Adult male and female Fisher 344 rats were fed control (no STG) or STG containing (1X and 7X, 1X=daily human dose) diets and sacrificed after 2 and 4 months. Serum chemistry analysis and histopathological examination of three vital target organs disclosed no adverse influence on protein, lipid and carbohydrate profiles, genomic integrity of the liver and/or the tissue architecture. However, analysis of the most important antioxidant components in the liver, kidney and heart homogenates revealed a dramatic increase in total glutathione concentrations, glutathione peroxidase and superoxide dismutase enzyme activities. Concomitantly, oxidative stress levels (malondialdehyde accumulation) in these three organs were less than control. Organ specific serum markers (ALT/AST for the liver; CPK/AST for the heart; BUN/creatinine for kidneys) and the genomic integrity disclosed no STG-induced alteration. Some of the serum components (lipid and protein) showed insignificant changes. Overall, STG-exposed rats were more active, and the results suggest that STG exposure produces normal serum chemistry coupled with elevated antioxidant capacity in rats fed up to seven times the normal human dose and does not adversely influence any of the vital target organs. Additionally, this study reiterates the potential benefits of exposure to a pharmacologically relevant combination of phytochemicals compared to a single phytochemical entity. — PMID: 20716937 [PubMed – indexed for MEDLINE]

IThis is how synergy can work with a combination of herbs and supplements–this is called Orthomolecular healing-using things of the body or of nature in adeqautes dosing or in combination to rebalance and restore the body to it’s norm

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3) Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy.

Med Oncol. 2010 Sep;27(3):919-25

Authors: Li GH, Wang DL, Hu YD, Pu P, Li DZ, Wang WD, Zhu B, Hao P, Wang J, Xu XQ, Wan JQ, Zhou YB, Chen ZT

Radiation-induced acute intestinal symptoms (RIAISs) are the most relevant complication of abdominal or pelvic radiation. Considering the negative impact of RIAIS on patients’ daily activities, the preventive effects of berberine on RIAIS in patients were investigated. Thirty-six patients with seminoma or lymphomas were randomized to receive berberine oral (n = 18) or not (n = 18). Forty-two patients with cervical cancer were randomized to a trial group (n = 21) and control group (n = 21). Radiotherapy used a parallel opposed anterior and posterior. 300-mg berberine was administered orally three times daily in trial groups. Eight patients with RIAIS were treated with 300-mg berberine three times daily from the third to the fifth week. Toxicities, such as fatigue, anorexia/nausea, etc., were graded weekly according to CTC version 2.0. Patients with abdominal/pelvic radiation in the control group showed grade 1 fatigue, anorexia/nausea, colitis, vomiting, proctitis, weight loss, diarrhea and grade 2 anorexia/nausea, fatigue. Only grade 1 colitis, anorexia/nausea, and fatigue were seen in patients of abdominal radiation treated with berberine. Grade 1 fatigue, colitis, anorexia/nausea, and proctitis occurred in patients of pelvic radiotherapy treated with berberine. Pretreatment with berberine significantly decreased the incidence and severity of RIAIS in patients with abdominal/pelvic radiotherapy when compared with the patients of the control group (P < 0.05). RIAIS were reduced in patients with abdominal radiotherapy/pelvic radiation after receiving berberine treatment. Berberine significantly reduced the incidence and severity of RIAIS and postponed the occurrence of RIAIS in patients with abdominal or whole pelvic radiation.

IThis can be found in Golden Seal ( if you use no more then 10 days on and a week off ) or Oregon Grape Make a tea with these or make an infusion with alcohol or dried in capsule

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4) Growth inhibition and cell-cycle arrest of human gastric cancer cells by Lycium barbarum polysaccharide.

Med Oncol. 2010 Sep;27(3):785-90

Authors: Miao Y, Xiao B, Jiang Z, Guo Y, Mao F, Zhao J, Huang X, Guo J

Lycium barbarum polysaccharide (LBP) is extracted from the traditional Chinese herb Lycium barbarum, and has potential anticancer activity. However, the detailed mechanisms are largely unknown. The purpose of this study was to observe the anticancer effect of LBP on human gastric cancer, and its possible mechanisms. Human gastric cancer MGC-803 and SGC-7901 cells were treated with various concentrations of LBP for 1-5 days, and cell growth was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Distribution of the cell cycle was analyzed by flow cytometry. Western blotting was used to indicate changes in the level of cyclins and cyclin-dependent kinases (CDKs). LBP treatment inhibited growth of MGC-803 and SGC-7901 cells, with cell-cycle arrest at the G0/G1 and S phase, respectively. We believe that this is the first study to show that LBP arrested different cell lines from the same types of cancer at different phases. The changes in cell-cycle-associated protein, cyclins, and CDKs were consistent with the changes in cell-cycle distribution. This study suggests that induction of cell-cycle arrest participates in the anticancer activity of LBP on gastric cancer cells. PMID: 19669955 [PubMed – indexed for MEDLINE]

IRemedy–Fused this in either alcohol or honey —Take a 1/4 cup of Goji Berry( wolfberry) and add either brandy-vodka-gin or a good wine at 1 1/2 cup in blender and blend for about 10 minutes at high speed – then pour contents through a sift and allow the mix to drain and pour content in a glass bottle–use 1/2 a teaspoon once or twice a day–this also improves the vision-increases liver support-brain support due to the S.O.D content ( Superoxide Dismutase ) which increases Glutathione( major antioxidant in the body ) –You can as well do this as an elixor By adding 1/4 cup of brandy 1/2-3/4 cup of honey and blend til liquified–then add 1/4 cup of goji berry to this and blend for 7-10 minutes at high speed -when done pour entire conten in a glass bottle and use agai 1/2 tsp 2 times a day or as needed

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5)The effect of probiotic microorganisms and bioactive compounds on chemically induced carcinogenesis in rats.

Neoplasma. 2010;57(5):422-8

Authors: Bertkova I, Hijova E, Chmelarova A, Mojzisova G, Petrasova D, Strojny L, Bomba A, Zitnan R

Diet interventions and natural bioactive supplements have now been extensively studied to reduce risks of colon cancer, which is one of the major public health problem throughout the world. The objective of our investigation was to study the effects of probiotic, prebiotic, nutritional plant extract, and plant oil on selected biochemical and immunological parameters in rats with colon cancer induced by N,N dimethylhydrazine (DMH). Male and female Wistar albino rats were were fed by a high-fat (HF) diet (10% fat in the diet) and were divided into 9 groups: Control group; PRO group – HF diet supplemented with probiotic Lactobacillus plantarum to provide 3 x 109 c.f.u. of strain/1 ml of medium; PRE group – HF diet supplemented with inulin enriched with oligofructose (2% of HF diet); HES group – HF diet supplemented with plant extract of Aesculus hippocastanum L.( Horse Chestnut ) (1% of HF diet); OIL group – HF diet comprised Linioleum virginale (2% of HF diet); and combination of probiotic microorganisms and bioactive compounds in the groups – PRO-PRE, PRO-HES, PRO-OIL, PRE-OIL. Carcinogenesis was initiated with subcutaneous injection of DMH (20 mg/kg) two times at week interval and dietary treatments were continued for the six weeks. Application of probiotic microorganisms and bioactive compounds in all treated groups significantly decreased the activities of bacterial enzymes (p<0.001), the fecal bile acids concentration (p<0.01; p<0.001) and significantly increased serum TNFalpha level (p<0.001) in comparison to the control rats. The number of coliforms was reduced in PRO, PRO-PRE, PRO-OIL and PRE-OIL groups and significantly higher count of lactobacilli (p<0.05) was observed in PRO-PRE, PRO-OIL and PRE-OIL groups in compare with the controls. In conclusion, the results of this study indicate that probiotic microorganisms and bioactive compounds could exert a preventive effect on colon carcinogenesis induced by DMH.— PMID: 20568896 [PubMed – indexed for MEDLINE]

ISo this is saying that if you are on a high fat and protein diet this can offset some of the side effects of this diet as well as neutralize cancer causing chemicals from reacting with the colon

 

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[U1]funny thing alot of us have been saying for a long time that the organics are not safe and the term we should really be using is pesticide free –chemical free–colour free–synthetic free if we are really trying to eat things as pure as possible—what we see is “ORGASMIC” may as well be as soon as people hear the term organic they assume thet have bitten into nirvana-well the truth is that we live in a world where gov’t have investments with corporations and so they legislate to protect there interest NOT OURS so if you have any intentions of buying anything then either buy direct from farmers especially those who have been bullied my the Globalist–

[U2]Does this make you feel better when you are eating soy?? a garbage food –leftover byproduct and waste which was coined as a health food which is worse then aspartame but when combo’d with aspartame is even more toxic due to the synergy–CHOW DOWN

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Show of the Week January 10 2011

 

INTRAVENOUS VITAMIN C SAVES NZ MAN WITH FLU DAMAGED LUNG

The Herxheimer Reaction – Feeling worse before feeling better

 

Not All Infant Formulas Are Alike– Differential Effects on Weight Gain

 

Recipe for Formula making for adult of child

 

Google map of Bird and Fish Fall out

 

Healing Autism: No Finer a Cause on the Planet

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INTRAVENOUS VITAMIN C SAVES NZ MAN WITH FLU DAMAGED LUNG
January 6, 2010 – 5:40 am

A 56 year old male was referred to Auckland Hospital ICU on 1 July 2009 with total respiratory failure, for ECMO external oxygenation. The patient had contracted H1N1 Swine flu (confirmed by tests) while on holiday overseas, and had developed what is known as ‘white out’ pneumonia. This refers to x-rays showing no air space in the lungs.–After 20 days of life-sustaining ECMO treatment and other critical care, the patient, who was unconscious by induced coma, had not responded. The ICU team advised the family of the likely outcome and had prepared them for the possibility of the patient’s death.—Family members approached Centre for Advanced Medicine Limited (CAM) for advice on the clinical use of intravenous vitamin C for such cases.—At the family’s request, information was provided to ICU doctors including ISO 9001:2008 registered protocols, safety data, dosages and access to vials of IV vitamin C under CAM’s license for wholesale medicines.—The ICU team agreed to administer intravenous vitamin C according to the family’s wishes. This decision acknowledged the family’s rights, in compliance with the New Zealand Health and Disability Act, 1997.—The patient received intravenous vitamin C starting on the evening of 21 July, continuing until 29 July. 25 grams was provided on the first day increasing over the first three days to 50 grams twice daily which was sustained for a further six days.—By 24 July x-rays indicated increasing lung function and ECMO external oxygenation was discontinued on 26 July. After several days of assisted ventilation and critical care for ongoing secondary conditions, the patient was able to commence his recovery and rehabilitation.—The patient was discharged from hospital on Friday 18 September, and is recovering at home on the farm.–The decision by the Auckland Hospital ICU team to administer adequate dosages of IV vitamin C, and their skillful coordination of ICU procedures, were responsible for the positive medical outcome.—Permission from the patient and his family has been sought by CAM to publish these details on its website and elsewhere in the interests of accuracy. This permission was willingly provided and CAM expresses its thanks, admiration and respect.–CAM welcomes opportunities to provide similar professional support for registered medical practitioners and their patients.

http://www.camltd.co.nz/h1n1.html

Spirited debate in Poland against the Vaccines on H1N1

Finnish Minster Against FLU SHOTS

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The Herxheimer Reaction – Feeling worse before feeling better

The Herxheimer Reaction is a short-term (from days to a few weeks) detoxification reaction in the body. As the body detoxifies, it is not uncommon to experience flu-like symptoms including headache, joint and muscle pain, body aches, sore throat, general malaise, sweating, chills, nausea or other symptoms. –This is a normal — and even healthy — reaction that indicates that parasites, fungus, viruses, bacteria or other pathogens are being effectively killed off. The biggest problem with the Herxheimer reaction is that people stop taking the supplement or medication that is causing the reaction, and thus discontinue the very treatment that is helping to make them better. Although the experience may not make you feel particularly good, the Herxheimer Reaction is actually a sign that healing is taking place.

What Is The Herxheimer Reaction?

The Herxheimer Reaction is an immune system reaction to the toxins (endotoxins) that are released when large amounts of pathogens are being killed off, and the body does not eliminate the toxins quickly enough. Simply stated, it is a reaction that occurs when the body is detoxifying and the released toxins either exacerbate the symptoms being treated or create their own symptoms. The important thing to note is that worsening symptoms do not indicate failure of the treatment in question; in fact, usually just the opposite.

A Rose By Any Other Name

Technically known as the Jarisch-Herxheimer Reaction, this syndrome goes by many names, including JHR, the Herxheimer Effect, the Herxheimer Response, a Herx Reaction, Herx or Herks. The most common terminology used is the Herxheimer Reaction. It is also often referred to as a healing crisis, a detox reaction, or die-off syndrome.

History

The phenomenon was first described by Adolf Jarisch (1860-1902) working in Vienna, Austria, and a few years later by Karl Herxheimer (1861-1942), working in Frankfort, Germany. Both doctors were dermatologists mainly treating syphilitic lesions of the skin. They noticed that in response to treatment, many patients developed not only fever, perspiration, night sweats, nausea and vomiting, but their skin lesions became larger and more inflamed before settling down and healing. Interestingly, they found that those who had the most extreme reactions healed the best and fastest. The patient might be ill for 2-3 days, but then their lesions resolved.

A Medical Example

The Herxheimer reaction is caused by the release of toxic chemicals (endotoxins) released from the cell walls of dying bacteria due to effective treatment. The Herxheimer Reaction is well recognized in medical circles and is certainly not confined to the world of natural medicine or supplements. –For example, a recent study report (Feb ’04) on the treatment of Sarcoidosis found that, “. . . without exception, the improving patients are reporting periodic aggravation of their symptoms as an apparent direct response to the antibiotics. In other words, these patients say that their treatment makes them feel much worse before they experience symptom-relief.” The abstract of the study goes on to say, “This phenomenon is known as the Jarisch-Herxheimer Reaction (JHR) and is often referred to informally as Herx. JHR is believed to be caused when injured or dead bacteria release their endotoxins into blood and tissues faster than the body can comfortably handle it. . . . This provokes a sudden and exaggerated inflammatory response . . . . In Sarcoidosis patients, the Herxheimer reaction seems to be a valuable indication that an antibiotic is reaching its target.” In the conclusion, the author states: “In my work with Sarcoidosis patients, it is my experience that recovering MP patients understand and welcome the Herxheimer reactions even when they must endure temporary increased suffering. They accept it as the price that they must pay in order to get well and they even seem to find it gratifying to experience tangible evidence of bacterial elimination. “

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Not All Infant Formulas Are Alike– Differential Effects on Weight Gain

ScienceDaily (Dec. 28, 2010) — New findings from the Monell Center reveal that weight gain of formula-fed infants is influenced by the type of formula the infant is consuming. The findings have implications related to the infant’s risk for the development of obesity, diabetes and other diseases later in life.—“Events early in life have long-term consequences on health and one of the most significant influences is early growth rate,” said study lead author Julie Mennella, Ph.D., a developmental psychobiologist at Monell. “We already know that formula-fed babies gain more weight than breast-fed babies. But we didn’t know whether this was true for all types of formula.”–While most infant formulas are cow’s milk-based, other choices include soy-based[U1] and protein hydrolysate-based formulas. Protein hydrolysate formulas contain pre-digested proteins and typically are fed to infants who cannot tolerate the intact proteins in other formulas.—In adults, pre-digested proteins are believed to act in the intestine to initiate the end of a meal, thus leading to smaller meals and intake of fewer calories. Based on this, the authors hypothesized that infants who were feeding protein hydrolysate formulas would eat less and have an altered growth pattern relative to infants feeding cow’s milk-based formula.–In the study, published online in the journal Pediatrics, infants whose parents had already decided to bottle-feed were randomly assigned at two weeks of age to feed either a cow’s milk-based formula (35 infants) or a protein hydrolysate formula (24 infants) for seven months.–Both formulas contained the same amount of calories, but the hydrolysate formula had more protein, including greater amounts of small peptides and free amino acids.—Infants were weighed once each month in the laboratory, where they also were videotaped consuming a meal of the assigned formula. The meal continued until the infant signaled that s/he was full.–Over the seven months of the study, the protein hydrolysate infants gained weight at a slower rate than infants fed cow milk formula. Linear growth, or length, did not differ between the two groups, demonstrating that the differences in growth were specifically attributable to weight.”All formulas are not alike,” said Mennella. “These two formulas have the same amount of calories, but differ considerably in terms of how they influence infant growth.”–When the data were compared to national norms for breast-fed infants, the rate of weight gain of protein hydrolysate infants was comparable to the breast milk standards; in contrast, infants fed cow’s milk formula gained weight at a greater rate than the same breast milk standards.–Analysis of the laboratory meal revealed the infants fed the protein hydrolysate formula consumed less formula during the meal.–“One of the reasons the protein hydrolysate infants had similar growth patterns to breast-fed infants, who are the gold standard, is that they consumed less formula during a feed as compared to infants fed cow’s milk formula” said Mennella. “The next question to ask is: Why do infants on cow’s milk formula overfeed?”–The findings highlight the need to understand the long-term influences of infant formula composition on feeding behavior, growth, and metabolic health. Future studies will utilize measures of energy metabolism and expenditure to examine how the individual formulas influence growth, and how each differs from breastfeeding.–Also contributing to the study, which was funded by the National Institute of Child Health and Human Development, were Monell scientists Gary Beauchamp and Alison Ventura.

Story Source:–The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Monell Chemical Senses Center, via EurekAlert!, a service of AAAS.–Journal Reference: Julie A. Mennella, Alison K. Ventura, and Gary K. Beauchamp. Differential Growth Patterns Among Healthy Infants Fed Protein Hydrolysate or Cow-Milk Formulas. Pediatrics, 2010; DOI: 10.1542/peds.2010-1675

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Recipe for Formula making for adult of child

—Get a Whey isolate or Whey Hydroslate 25-28 grams Unflavoured or Neutral or Natural and Add Mct 1-2 tablespoons –and add either vanilla or cocoa And sweeten with either Unpasteurized hone ot Maple syrup or Xylitol or Stevia ad 1-1 ½ cup of water all in a blender—you can substitute the cocoa for even fruit or almond extract or orange extract or add the cocoa and peppermint extract 1-3 drops of any of the extracts or 1 tablespoon of vanilla—blend for 4-5 minutes —this can be used as a pre meal for utilizing this to curb appetite —you can take it In between meals as well as a protein supplement—you can warm this and give it to infants but reduce the gram dosage to about ¼ -1/3 so 28 grams would be about 7-9 grams and reduce the MCT to 1 tablespoon

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Google map of Bird and Fish Fall out

http://maps.google.com/maps/ms?ie=UTF8&hl=en&oe=UTF8&msa=0&msid=201817256339889828327.0004991bca25af104a22b

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FEAT


“Healing Autism: No Finer a Cause on the Planet
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January 20, 2001 Search http://www.feat.org/search/news.asp

[This Sunday Herald (UK) article is another treatment of the same MMR – vaccine story in previous newsletter post.] http://www.sundayherald.com/news/newsi.hts?section=News+Focus&amp;story_id=13820

Amid claims that the MMR triple vaccine can cause autism, Dr Andrew Wakefield insists in a new report that it should never have got a licence–Five years ago, Dr Andrew Wakefield was approached by parents who told him a tragic story. Their children had been developing normally until the toddlers were given the vaccine for measles, mumps and rubella, MMR. The parents said they then witnessed a regression in their children’s behaviour and speech, as well as the onset of an unpleasant bowel disorder. Presented with similar accounts by numerous sets of parents, the London doctor decided to investigate. What he discovered was to provoke one of the most bitter vaccination controversies ever. Today, he has a paper published in the Journal of Adverse Drug Reactions. It concludes that the vaccine for measles, mumps and rubella should not have been licensed in 1988 because inadequate research had been carried out. The conclusion is backed up by four senior figures in medicine regulation, including Dr Peter Fletcher, a former senior scientific civil servant and assessor to the Committee on Safety of Medicines. They say children given the vaccine in trials should have been monitored for much longer because adverse reactions could have taken several months to show.–They also say there was little information on the effects of giving three live vaccines together, compared with giving them separately. Wakefield’s original theory was published in The Lancet in 1998. He then extended his work and further findings were published in the American Journal of Gastroenterology. His most up-to-date work on 170 children is soon to be published.—Last year, Professor John O’Leary, director of pathology at Coombe Women’s Hospital in Dublin, uncovered evidence pointing to a link between the MMR vaccine and autism in children. His findings, presented to a US Congressional hearing earlier this month, backed up Wakefield’s Lancet study. But, despite having been peer-reviewed, other experts insist there is no evidence to suggest a link. A three-year war has ensued between Department of Health scientists, who are struggling to maintain confidence in the vaccination programme , and researchers such as Wakefield and O’Leary. Speaking from his London home, Wakefield explained that his duty is to his patients, regardless of how much his findings upset the Department of Health. He said: “At first, we were sceptical but the parents’ story was so consistent that we felt we had to investigate. When the parent tells you they believe the problems started after exposure to the MMR vaccine, do you say, ‘That is very interesting but politically it makes me very uncomfortable’? -“I represent patients whose parents say to me, ‘This is what happened to my child: At one point, my child was developing normally, then they encountered the MMR and they developed autism.’ They say their children became badly behaved, developed terrible bowel problems and their communication regressed. They said there is an epidemic of this problem but the medical profession told them they were wrong.–“We had to take their story at face value and to investigate it. What we found, to our surprise, was that the parents were right.” Government scientists have heavily criticised Wakefield and his research. They claim his science has not been reproduced by either himself or other scientists – an allegation he disputes. —The hostilities penetrate down to the hospital where he works, the Royal Free in London. While Wakefield is carrying out his research, Professor Brent Taylor – head of the department of paediatrics and child health at the hospital – does his best to convince the public that the link does not exist. Professor Taylor told the Sunday Herald: “There are no serious side- effects and the MMR does not cause autism and inflammatory bowel disease. Nobody anywhere else in the world has been able to reproduce any of Wakefield’s studies. “Separate vaccines do not provide good protection for children. We do not want a new programme that could result in serious diseases which kill and maim people.”–The publication of a paper in the Journal of Adverse Drug Reactions saying that the MMR should never have been licensed caused a damaging row between the editor and the head of immunisation in Scotland. Dr Ian Jones, director of the Scottish Centre for Infection and Environmental Health, wrote to the editor, Dr John Griffin, suggesting that the journal should not publish the controversial paper. This prompted Griffin to accuse Jones of trying to censor the journal.–Wakefield’s claims that a major government vaccination programme is causing children to become autistic are so damaging that his trust usually bans him from speaking to the media. Whenever the MMR debate is re fuelled by new claims, receptionists at the Royal Free Hospital are put on alert and any journalists asking to speak to the doctor are redirected to the trust’s official spokesman.–But, this weekend, Wakefield has been given permission to discuss his latest research. He is adamant that, despite being the subject of bitter personal criticism, his arguments will be based on his science. He does, however, express regret that the strength of government opposition is hindering the research.–He said: “I don’t want to moan about what has happened to me. We have got to fight this on the science. You go into this sort of thing with your eyes open. Yes, you are taking on your colleagues, the health department and the biggest drug companies in the world but the question you have to ask is, ‘Who do you represent?’ “My responsibility is to the patient and not to the Department of Health. I am not going to decide against investigating something because of the possible consequences for the Department of Health, because it may make things difficult for them. “The frustration is more that we are restricted in our attempts to help the children in the way that we would like to. It is becoming incredibly difficult to get funding for further investigations and clinical trials.”Discussing the paper to be published today, Wakefield points out that while the government scientists had until now directed their criticism at him, they must admit that they are also criticising former members of their own department.He said: “Government scientists were critical of our science but the work was peer-reviewed, unlike other papers, because of the controversial nature of the subject. This paper went to four reviewers who agreed to have their comments published. “We agreed to have that done not knowing what they would say and that is the way that science should be conducted. They have come out being very supportive. These are people who are not anti-vaccine but eminent people involved in drug regulation. The regulators themselves are saying that the vaccine was not safe.”-He added: “If they want to attack me, that’s fine but now they are bringing in four eminent regulators. Are they going to denounce the very valid opinions of their own colleagues?” Wakefield first suggested in 1998 that single vaccines should be made available on the basis of the fears of a link between the MMR and autism and inflammatory bowel disease. He says the findings of the latest report reinforces the need to make mono valent vaccines available now.–He said: “It is absolutely no good to come out with tired rhetoric claiming that the vaccine has been proven to be safe. I am afraid that that is not the case. Until this is resolved, single vaccines must be made available.–“The concerns have been dismissed by the Department of Health but doctors, practice nurses and health visitors are changing their minds. “I have referrals at the moment from paediatricians who believe their patients have been damaged by the MMR. We get this time and time again. The change in attitude is very telling.”–In May last year, Wakefield sent a copy of his latest paper to Dr Liam Donaldson, the Chief Medical Officer for England. He said: “I was giving them the option to provide supplies of monovalent vaccines because I did expect there to be a scare. I did that knowing that they could use it against us by attempting to undermine the paper but it would have been morally wrong just to let it appear on the news stands on Monday. What they chose to do with that information I do not know.”—Wakefield suggests vaccinating against measles at 15 months, against mumps when the child is three years old and against rubella when the child is four.–“What they are saying is that I could be responsible for an epidemic – children would suffer and some may die. But my point of view is pro vaccine. Nobody is saying, ‘Do not protect children against measles.’ This is about the safest way to do it. There is no need for measles to come back if we vaccinate against measles at 15 months. “I have been honest and have published data whether it is positive or negative. Thus far, the parents have been absolutely right and I am obliged to continue to take this to its natural conclusion. In the meantime, I think parents deserve the option of single vaccines.”–This month, the Scottish parliament has come under increasing pressure from MSPs to reintroduce single vaccines. Wakefield hopes that this may become a reality. “The Scottish parliament has a unique opportunity, having devolved from the power of Whitehall, to take important decisions. The people are closer to their representatives, who seem prepared to listen.”

 

TOP B

[U1]MOST are that today rarely do you see a dairy based formula with out soy or aspartame or canola in the mix
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HOME

 

Show of the Week January 14 2011

 

Making a Laundry Soap—Clean Soap

 

Study Probes Obesity Link to Fibromyalgia

 

Tablet Splitting Is a Highly Inaccurate and Potentially Dangerous Practice

 

Scientist Shows Link Between Diet and Onset of Mental Illness

 

HRT=Misery

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Making a Laundry Soap—Clean Soap

 

 

Making a Laundry Soap—Clean Soap

You will need one bar of lye soap

You will need 1 cup of borax

You will need ½ cup of baking soda

And water and a 5 gallon container

 

Shred the soap with a grader and pour the contents into a pot adequately sized

With water to take the pulverized soap—then add new water to the 5 gallon container half way with water—then add the liquefied soap water from the pot into the container and whisk together with a whisker—add the 1 cup of borax and add the ½ cup of baking soda ( you can add an essential oil for scent if you like such as lime –lemon –orange etc) whisk again til completely mixed-then allow to set over night—it will cogeal ( solidify like jello) then take a 2 litre ( quart ) container fill with water half way with water—then take the whisker and mix the jello soap till liquid again and pour to top off the container—can be used for clothes using 2-3 oz at a time –can be used as well for doing dishes—Will make 5 gallons for a bout 5 dollar total investment –so for about 2.50 you can make 5 gallons of cleaning soap

 

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Study Probes Obesity Link to Fibromyalgia

ScienceDaily (Jan. 1, 2011) — Afflicting up to 5 percent of the U.S. population, mostly women, fibromyalgia is characterized by widespread pain and range of function problems. A new study in The Journal of Pain reports there is close association between obesity and disability in fibromyalgia patients.—The purpose of the study, conducted by University of Utah researchers, was to evaluate the relationship between fibromyalgia and obesity. They hypothesized that obesity significantly adds to the disease and disability burden of the condition. Two hundred fifteen fibromyalgia patients were evaluated in the study and given several physical tests to measure strength, flexibility, range of motion, and strength. Heart rates and sleep quality also were assessed.—The authors reported that consistent with previous studies, obesity is common among those with fibromyalgia. Half the study sample was obese and an additional thirty percent were overweight. Also consistent with previous findings, obese patients in this study showed increased pain sensitivity, which was more pronounced in lower body areas. The obese patients also had impaired flexibility in the lower body and reduced strength.–The study concluded that obesity is a common comorbidity of fibromyalgia that may compromise clinical outcomes. The adverse impact of obesity is evidenced by hyperalgesia, disability, impaired quality of life and sleep problems. The authors also noted that recent evidence suggests weight loss improves fibromyalgia symptoms, perhaps resulting from patients adopting healthier lifestyles and taking more positive attitudes toward symptom management, and overall quality of life. Story Source–The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by American Pain Society.–Journal Reference:–Akiko Okifuji, Gary W. Donaldson, Lynn Barck, Perry G. Fine. Relationship Between Fibromyalgia and Obesity in Pain, Function, Mood, and Sleep. The Journal of Pain, 2010; 11 (12): 1329 DOI: 10.1016/j.jpain.2010.03.006

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Tablet Splitting Is a Highly Inaccurate and Potentially Dangerous Practice

 

ScienceDaily (Jan. 7, 2011) — Medical experts have issued a warning about the common practice of tablet splitting, after a study found that nearly a third of the split fragments deviated from recommended dosages by 15 per cent or more.–Their study, published in the January issue of the Journal of Advanced Nursing, points out that the practice could have serious clinical consequences for tablets that have a narrow margin between therapeutic and toxic doses.–And they are calling on manufacturers to produce greater dose options and liquid alternatives to make the practice unnecessary.–Researchers from the Faculty of Pharmaceutical Sciences at Ghent University, Belgium, asked five volunteers to split eight different-sized tablets using three techniques commonly used in nursing homes.–They found that 31 per cent of the tablet fragments deviated from their theoretical weight by more than 15 per cent and that 14 per cent deviated by more than 25 per cent. Even the most accurate method produced error margins of 21 per cent and eight per cent respectively. “Tablet-splitting is widespread in all healthcare sectors and a primary care study in Germany found that just under a quarter of all drugs were split” says study lead Dr Charlotte Verrue.–“It is done for a number of reasons: to increase dose flexibility, to make tablets easier to swallow and to save money for both patients and healthcare providers. However, the split tablets are often unequal sizes and a substantial amount of the tablet can be lost during splitting.”—The five researchers comprised a pharmacy student, researcher and professor, an administrative worker and a laboratory technician, ranging from 21 to 55 years of age. With the exception of the technician, none of the other study participants had tablet-splitting experience. The authors believe this replicated nursing home conditions where splitting is not always performed by professional nurses.–Between them they split tablets into 3,600 separate quarters or halves using a splitting device, scissors and a kitchen knife. The eight different tablets were different shapes and sizes, three were unscored, three had one score line and the others had two.—The drugs were prescribed for a range of health conditions, including Parkinson’s, congestive heart failure, thrombosis and arthritis.—After splitting, each fragment was weighed to see how much they deviated from the theoretical weight.

Key results included:

Using a splitting device was the most accurate method. It still produced a 15 to 25 per cent error margin in 13 per cent of cases, but this was lower than the 22 per cent for scissors and the 17 per cent for the knife.
The splitting device produced a deviation of more than 25 per cent in eight per cent of cases, compared with 19 per cent for the scissors and 17 per cent for the knife.
Some drugs were much easier to split accurately than others. The easiest to split produced an overall error margin (15 per cent deviation or more) of two percent and the most difficult tablets produced an error margin of 19 per cent.
“Tablet splitting is daily practice in nursing homes” says Dr Verrue. “However, not all formulations are suitable for splitting and, even when they are, large dose deviations or weight losses can occur. This could have serious clinical consequences for drugs where there is a small difference between therapeutic and toxic doses.—“Based on our results, we recommend use of a splitting device when splitting cannot be avoided, for example when the prescribed dose is not commercially available or where there is no alternative formulation, such as a liquid.–“Staff who are responsible for splitting tablets should receive training to enable them to split as accurately as possible. They should also be made aware of the possible clinical consequences of dose deviations.–“We would also like to see manufacturers introduce a wider range of tablet doses or liquid formulations so that tablet splitting becomes increasingly unnecessary.”Story Source-The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Wiley – Blackwell, via AlphaGalileo.–Journal Reference–Charlotte Verrue, Els Mehuys, Koen Boussery, Jean-Paul Remon, Mirko Petrovic. Tablet-splitting: a common yet not so innocent practice. Journal of Advanced Nursing, 2011; 67 (1): 26 DOI: 10.1111/j.1365-2648.2010.05477.x

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Scientist Shows Link Between Diet and Onset of Mental Illness

ScienceDaily (Dec. 13, 2010) — Changes in diet have been linked to a reduction of abnormal behaviors in mentally ill people or animals, but a Purdue University study shows that diet might also trigger the onset of mental illness in the first place.–Joseph Garner, an associate professor of animal sciences, fed mice a diet high in sugar and tryptophan that was expected to reduce abnormal hair-pulling. Instead, mice that were already ill worsened their hair-pulling behaviors or started a new self-injurious scratching behavior, and the seemingly healthy mice developed the same abnormal behaviors.–“This strain of mouse is predisposed to being either a scratcher or a hair-puller. Giving them this diet brought out those predispositions,” said Garner, whose results were published in the December issue of the journal Nutritional Neuroscience. “They’re like genetically at-risk people.”–Garner studies trichotillomania, an impulse-control disorder in which people pull out their hair. The disorder, which disproportionately occurs in women, is thought to affect between 2 percent and 4 percent of the population. Mice that barber, or pull their hair out, have been shown to have low levels of serotonin activity in the brain. That neurotransmitter is known to affect mood and impulses. Garner hypothesized that increasing serotonin activity in the brain might cure or reduce barbering and possibly trichotillomania.–Serotonin is manufactured in the brain from the amino acid tryptophan, which is consumed in diets. The problem is that tryptophan often doesn’t make it across the barrier between blood and the brain because other amino acids can get through more easily and essentially block the door for tryptophan. Garner modified a mouse diet to increase simple carbohydrates, or sugars, and tryptophan. The sugars trigger a release of insulin, which causes muscles to absorb those other amino acids and gives tryptophan a chance to make it to the brain.–Using eight times as much sugar and four times as much tryptophan, Garner observed a doubling of serotonin activity in the brain. But the mice that barbered did not get better.—“We put them on this diet, and it made them much, much worse,” Garner said.–A second experiment divided the mice into three groups: those that were seemingly normal, others that had some hair loss due to barbering and a group that had severe hair loss. All the mice soon got worse, with conditions escalating over time.–“Three-quarters of the mice that were ostensibly healthy developed one of the behaviors after 12 weeks on the new diet,” Garner said.–Some of the mice developed ulcerated dermatitis, a fatal skin condition thought to be caused by an unidentified pathogen or allergen. Garner saw that the only mice that contracted the condition were the scratchers.—“What if ulcerated dermatitis, like skin-picking, another common behavioral disorder, is not really a skin disease at all?” Garner said. “We now have evidence that it may be a behavioral disorder instead.” When taken off the new diet, the negative behaviors stopped developing in the mice. When control mice were switched to the new diet, they started scratching and barbering.—Garner’s study raises questions of how diet might be affecting other behavioral or mental illnesses such as autism, Tourette syndrome, trichotillomania and skin-picking. He said that before now, a link between diet and the onset of mental disorders hadn’t been shown.–“What if the increase of simple sugars in the American diet is contributing to the increase of these diseases?” Garner said. “Because we fed the mice more tryptophan than in the typical human diet, this experiment doesn’t show that, but it certainly makes it a possibility.”—Garner next wants to refine the experiments to better imitate human dietary habits, including the amount of tryptophan people consume. Internal Purdue funding paid for his work. Story Source–The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Purdue University, via EurekAlert!, a service of AAAS. Journal Reference–Brett D. Dufour, Olayiwola Adeola, Heng-Wei Cheng, Shawn S. Donkin, Jon D. Klein, Edmond A. Pajor, Joseph P. Garner. Nutritional up-regulation of serotonin paradoxically induces compulsive behavior. Nutritional Neuroscience, 2010; 13 (6): 256 DOI: 10.1179/147683010X12611460764688

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HRT=Misery

 

Potential ‘Safe Period’ For Hormone Replacement Use Identified

ScienceDaily (Feb. 8, 2009) — A new study makes important new findings on the role of hormone use on the risk of breast cancer, confirming that the use of estrogen plus progesterone increases the risk of both ductal and lobular breast cancer far more than estrogen-only; suggesting a two-year “safe” period for the use of estrogen and progesterone; and finding that the increased risk for ductal cancers observed in long-term past users of hormone replacement therapy drops off substantially two years after hormone use is stopped.–Previous studies have shown that hormone replacement therapy after menopause increases the risk of breast cancer and that use of a regimen that includes both estrogen and progesterone is more detrimental for the breast than the use of estrogen alone. But more data from large prospective studies are needed to fully characterize the impact of exogenous hormones (Exogenousor exogeneous) refers to an action or object coming from outside a system. It is the opposite of endogenous, something generated from within the system ) on breast cancer incidence by type of hormone preparation and histology of the cancer.—To investigate the association in more detail, American Cancer Society epidemiologists led by Eugenia E. Calle, PhD, did a prospective study of 68,369 postmenopausal women who were cancer-free at baseline in 1992. They examined the use of estrogen-only and estrogen and progesterone in current and former users of varying duration, and the subsequent risk of developing invasive ductal and lobular carcinoma of the breast. They also looked at whether the risk for each type of breast cancer and each type of hormone regimen varied by body mass index (BMI), stage of disease at diagnosis, and estrogen receptor (ER) and progesterone receptor (PR) status. For the present study, the follow-up period ended on June 30, 2005.—They confirmed the findings from previous work that estrogen and progesterone increases the risk of both ductal and lobular breast cancer far more estrogen alone. They also found the risk associated with use of estrogen and progesterone increases significantly and substantially within three years of beginning hormone use. The data showed no increased risk for women who used estrogen and progesterone for less than two years, potentially identifying a “safe” period for estrogen and progesterone use.—The study also found no increased risk of breast cancer in women who had stopped using estrogen and progesterone two or more years ago, suggesting a window of two to three years for the risks of estrogen and progesterone both to become apparent after initial use and to diminish after cessation. Few estimates of risk within two to three years of initiation and cessation are available, so these findings need replication in other large studies. The study found the use of estrogen and progesterone was associated with a doubling of risk of lobular cancer after three years of use, and a doubling of risk of ductal cancer with 10 years of use. Estrogen-only use was not associated with increased risk of ductal cancer, even after 20 years of use, but was associated with a 50 percent increase in risk of lobular cancer after 10 years of use.—Story Source: The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by American Cancer Society, via EurekAlert!, a service of AAAS. — Journal Reference: –Eugenia E. Calle et al. —Postmenopausal hormone use and breast cancer associations differ by hormone regimen and histologic subtype. Cancer, Published Online: January 20, 2008 DOI: 10.1002/cncr.24101

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Long-Term Estrogen Therapy Linked To Breast Cancer Risk

ScienceDaily (May 9, 2006) — Long-term estrogen therapy may be related to a higher risk of breast cancer among postmenopausal women who have had a hysterectomy, according to an article in the May 8 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. —Previous studies have linked the use of hormone therapy to breast cancer among postmenopausal women, but have primarily focused on the hormone combination of estrogen plus progestin, according to background information in the article. Recently released results from the Women’s Health Initiative (WHI), a large clinical trial of hormone therapy, found no significant link between estrogen therapy and breast cancer in women who took the hormone for seven years. —Wendy Y. Chen, M.D., M.P.H., Brigham and Women’s Hospital and Dana Farber Cancer Institute, Boston, and colleagues evaluated women who were part of the Nurses’ Health Study, a group of female nurses that have been followed since 1976. In 1980, 11,508 women from the study were postmenopausal and had had a hysterectomy. Every two years the researchers enrolled all the additional women who become postmenopausal and had a hysterectomy, so 28,835 women were included by the end of the study in 2002. Women were asked by questionnaire every two years if they used hormones and whether they had developed breast cancer. For women who developed breast cancer, the researchers obtained permission to review the women’s medical records, which they used to record the hormone receptor information. Tumors were classified as positive or negative for estrogen receptor or progesterone receptor based on how they responded to specific hormonal therapies. —Throughout the study period, 934 invasive breast cancers developed, 226 among women who had never used hormones and 708 among women who were using estrogen at the time. The longer a woman used estrogen, the higher her risk of breast cancer. Those who had been taking estrogen for fewer than 10 years did not appear to have a higher risk than those who had never taken hormones, but those who had been taking estrogen for more than 20 years had a significantly increased risk. The association was strongest for cancers that were estrogen receptor positive and progesterone receptor positive. The results were similar when the researchers evaluated only women who were older than age 60; only women who had begun estrogen therapy after reaching age 50; and only women who were at least age 50 and had undergone a hysterectomy, even if they had not gone through menopause. —“In conclusion, we found that estrogen therapy was associated with an increased risk of breast cancer with longer-term use,” the authors write. “Although current use of estrogen therapy for less than 10 years was not associated with a statistically significant increase in breast cancer risk, the WHI has shown an increased risk of stroke and deep-vein thrombosis in the same time period. Women who take estrogen therapy for prevention or treatment of osteoporosis typically require longer-term treatment and should thus explore other options, given the increased risk of breast cancer with longer-term use.”—(Arch Intern Med. 2006; 166: 1027-1032. Available pre-embargo to media at http://www.jamamedia.org.) –Editor’s Note: This study was supported by a grant from the National Institutes of Health, Bethesda, Md. —Story Source: The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by JAMA and Archives Journals, via EurekAlert!, a service of AAAS —

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Estrogen Therapy May Be Associated With Kidney Stones in Postmenopausal Women