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Potential use of Piper nigrum ethanol extract against pyrethroid-resistant Aedes aegypti larvae.

Simas NK, Lima Eda C, Kuster RM, Lage CL, de Oliveira Filho AM.

Núcleo de Pesquisas de Produtos Naturais, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ.

Abstract

Fractionation of Piper nigrum ethanol extract[U3], biomonitored by assays on pyrethroid-resistant Aedes aegypti larvae yielded isolation of the larvicidal amides piperolein-A and piperine. Comparing LC50 values, the ethanol extract (0.98 ppm) was the most toxic, followed by piperolein-A (1.46 ppm) and piperine (1.53 ppm

Recipe- Get the essential oil of black pepper and add 10 drops to 8 oz of alcohol and add to it garlic extract ( if desired or for out door use ) and spray the area or clothing you are wearing—or take black pepper and fuse into a blender with alcohol and allow to blend for 10 minutes and then strain afterwards with a handkerchief ( to increase the potency put in the strained alcohol and add more pepper and blend again for another 5 minutes and then strain) this will concentrate this more so—and again use on clothing or areas of problems—direct contact to the skin may cause some irritation for some —but usually actsas a pain deterrent

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Commission requests urgent safety review of aspartame from EFSA
The European Commission has asked EFSA to conduct a full re-evaluation of the safety of aspartame by July 2012, due to MEPs’ concerns and EFSA’s decision to look more closely at two recent studies on carcinogenicity and pregnancy effects.

EFSA spokesperson Lucia de Luca told FoodNavigator.com that the agency has received a mandate for a complete re-evaluation of aspartame, and that the scientists are “looking at it and verifying what the risk manager is looking for”. While EFSA has not yet completed the administrative work to accept the request, a full review of aspartame was already planned for 2020; EFSA has been reviewing the safety of all food additives previously approved for use in the EU, and having made its way through colours and flavourings, sweeteners were the last category to be looked at. A spokesperson for John Dalli, Commissioner for Health and Consumers, said there are several reasons for bringing forward the review with a 13-month deadline. –Firstly, he said “there have been concerns lately and questions from MEPs”. At the second reading of the proposed food information regulation last month MEPs voted for a mandatory warning label on products about aspartame consumption in pregnancy. —In addition, he said EFSA said earlier this year that two recent studies on aspartame, a mouse study on carcinogenicity and an epidemiological study in sweeteners and pre-term delivery, did not give reason to reconsider safety of aspartame and over approved sweeteners – but subsequently decided to do an in-depth study. EFSA’s scientific opinion on interpretation of the results of the carcinogenicity study, as well as suggested implications of methanol reported in both studies, is due by the end of this year. Commenting on bringing forward the full re-evaluation, de Luca said: “It is fine if we have to do it before.”

Will MEPs heed opinion?

There is no guarantee that the MEPs’ call for warning labels on aspartame will be hushed until the findings of the full re-evaluation are published next year, however. -Dalli’s spokesperson said: “EU decisions have to be based on science.” There is a precedent of MEPs pressing ahead with actions before EFSA’s opinion is available, however. In 2008 they succeeded in a last minute addition to the FIAP additives package requiring a warning label on products containing the so-called Southampton colours due to hyperactivity concerns. In EFSA’s opinion the Southampton study did not give scientific grounds for linking the colours to hyperactivity in children.[U4] The spokesperson said that in this case “there was more nuance in some phrases” which may indicate the colours could be problematic for some consumers. There has already been a clash between MEPs and EFSA over aspartame. In March the agency expressed disappointment over the Parliament’s reporting of a hearing over aspartame in which it participated. –It said in a statement: “Unfortunately, when reporting the outcomes of this meeting, the organisers of the hearing continue to repeat errors and misinformation. EFSA reaffirms that any possible risks from aspartame have been considered by scientific bodies worldwide and the current Acceptable Daily Intake (ADI) ensures consumers are protected.” [U5]–A spokesperson for aspartame producer Ajinomoto declined to comment on the mandate for earlier re-evaluation of the sweetener until EFSA has communicated its acceptance

 

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Chlorine and Childhood Cancer

ScienceDaily (May 25, 2011) — A significant positive association between the risk of childhood leukemia and levels of chlorine-containing chemicals in the atmosphere has been found by researchers in Portugal. Details are reported in the current issue of the International Journal of Environment and Health.–Maria do Carmo Freitas of the Technological and Nuclear Institute in Sacavém, Portugal, and statistician Maria Martinho of the Department of Economic and Social Affairs at the United Nations Headquarters in New York, USA, emphasise that potential emissions from paper-related industry, forest fires, pesticides manufacturing, heavy chemical industry and fossil fuel power stations may lead to higher levels of chlorine-containing carcinogens in the air.–Freitas and colleague have investigated the correlation between atmospheric pollution levels of 22 chemical elements, including arsenic, nickel, lead and mercury, as gleaned from an analysis of lichens used as biomarkers of these pollutants and looked at the leukemia deaths in 275 counties across Portugal.—They explain how lichens have been used as accurate biomarkers of pollution levels since the 1970s. Lichens are excellent biomonitors because they depend largely on atmospheric depositions for their nutrient supply, thus showing elemental compositions which reflect the gaseous, dissolved and/or particulate elements in the atmosphere, the team explains. Collecting and analysing lichens across a large geographical area thus reveals the elements present in the air across that area and so gives researchers a map of pollutants which can be overlaid with epidemiological data, on leukemia incidence, for example.—The team further explains that leukemia typically results from malignant transformation of white blood cells and accounts for almost a third of all cancers in children under the age of fifteen years. In Portugal, during the period 1970 to 1999 there were 30 cases per million children each year on average. However, while some evidence has linked the disease to exposure to ionising radiation or to the known carcinogen benzene the cause of most cases remains unknown. Previous work has also found no correlation between atmospheric levels of arsenic, mercury nickel and lead as revealed by lichen surveys. However, chlorine-content has been associated with the incidence of diabetes and there are significant associations with malignant growths and bromine, iodine, nickel, lead, sulfur, antimony and vanadium contents of lichens.–“The significant association found of course does not imply causality,” explains Freitas. “More research will be needed to confirm causality and if so the underlying mechanisms.”–Story Source-The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Inderscience, via AlphaGalileo.–Journal Reference-Maria do Carmo Freitas, Maria Martinho. Investigation of associations between chemical element contents in native lichens and childhood leukaemia. International Journal of Environment and Health, 2011; 5 (1/2): 125 DOI: 10.1504/IJENVH.2011.039861

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[U1]Sunflower Lecithin has 25% more Phostadyl Choline then soy lecithin and far safer and better–in my opinion any thing derived from soy has toxic issues til now we only had 1 other choice for lecithin and that was egg yolk ( the very thing they keep everyone away from ) which has some of the best healing and supportive elements for the body
[U2]Again In combination with tumeric should see an increased sensitivity to insulin and utilization of Sugar should improve dramatically –Drug free—the key is as well to Support the Pancreas since there is a direct correlation with the liver in the utilization of sugar and other foods
[U3]Pepper and Alcohol
[U4]This has been know for over 50 years—
[U5]This again is misleading and is showing the Globalist who own Asprtame are protecting ther einterest at the expense of selling ant neurotoxoc sweeteners

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Show of the Week May 30 2011

FDA rejects homotaurine NDI bid; finds it is not an amino acid
Big Island Dairy Farmers fight radiation with Boron

 

Acetaminophen tied to blood cancers

 

Free Iodine Therapeutic Application. .

 

Antioxidant activity and mechanism of action of thymol and carvacrol in two lipid systems

 

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FDA rejects homotaurine NDI bid; finds it is not an amino acid
The Food and Drug Administration has rejected Canadian biotech firm Ovos’s bid to win NDI status for its homotaurine brain health ingredient because the agency says the nutrient found in certain seaweeds is not an amino acid.

In handing its belated response to Ovos’ new dietary ingredient (NDI) petition that was lodged more than 18 months ago, FDA issued a seven-page document detailing why homotaurine is not an amino acid and did not fit any other dietary ingredient category as listed under section 201(ff)(1) of the Food, Drugs and Cosmetics Act (FDCA[i1] ). FDA said that for the purposes of that section of the FDCA, “the term ‘amino acid’ refers to an alpha-amino carboxylic acid used as a constituent of proteins or peptides. Homotaurine is a gamma-amino sulfonic acid. It is not an alpha-amino carboxylic acid or a constituent of proteins.” It therefore could not be considered for NDI status, FDA said, adding that the fact Ovos’s homotaurine form was synthetically manufactured also disqualified it. Ovos was sold by Bellus Health to Advanced Orthomolecular Research at the end of 2010. The two companies negotiated an exclusive license and supply agreement for Vivimind, the proprietary version of homotaurine. Responding to the FDA decision, Bellus-Ovos’s attorney Marc Ullman questioned the FDA’s amino acid classification criteria. “Obviously we are extremely disappointed by the FDA’s decision,” he told NutraIngredients-USA.com from the Focus on the Future Conference in Arizona.

“When I look at the Dietary Supplements and Health Education Act (DSHEA), I see the words ‘amino acid’, I don’t see the words ‘some amino acids’.”

Hyper-technical argument

Bellus Health itself was not available for comment at the time of publication but Ullman said it had instructed him and other experts to, “review the validity of FDA’s hyper-technical argument”. -He said the company and his team were “particularly troubled” by the fact that homotaurine had previously been classified as an amino acid when the compound had been considered and approved for use by the FDA in a drug called Campral.

Commenting on the decision, Ricardo Carvajal, from the Washington DC office of legal firm, Hyman, Phelps & McNamara, observed on a blog: “The response also suggests that FDA can be expected to closely scrutinize the applicability of the definition of ‘dietary supplement’ to synthetic substances that are not already part of the food supply.” This distinction was noted in a NutraIngredients-USA story this week about synthetic versions of geranium extracts.

To read that story click here.

Drug-supplement switch

Bellus/Ovos was trying to break new ground with its NDI petition by becoming the first firm to have an ingredient switched from drug to supplement status after its initial efforts to have the ingredient win drug approval fell short at the clinical trial stage. If the application had been accepted, the FDA would have been required to “promulgate regulations” to accommodate the drug-supplement shift. Vivimind is approved for use in dietary supplements in Italy and Spain and Health Canada has approved it under its Natural Health Products Directorate.

Ovos’s original petition can be found here .

The FDCA seeks to protect the pharmaceutical market by stating that a substance cannot be marketed as a dietary supplement if it has been authorized for investigation as a new drug “unless the Secretary, in the Secretary’s discretion, has issued a regulation, after notice and comment, finding that the article would be lawful under this Act”.

 

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Big Island Dairy Farmers fight radiation with Boron

In the past weeks radioactive levels have increased in Hawaii, with high spikes and a more current leveling off of radiation levels. Milk from the large dairies in Hamakua and Hawi has shown elevated levels of radiation, from 400 to 2400 times the recognized safe levels.–Why is milk contamination significant in the world of agriculture? Because milk represents the overall condition of the entire food chain, since cows consume grass and are exposed to the same elements as crops. So, when milk tests positive for radiation, it indicates the entire food chain is contaminated since cows eat grass. When grass is contaminated everything grown in the same soil is contaminated. This has proposed a serious concern to us farmers, with us asking what can we do? After much consideration, research, and conversations with much appreciated experts in the field of biological farming and human & animal health, we have found some things which we are able to do to protect our soil, animals, and bodies.—Aside from the much recognized supplement potassium iodine as a protection against radioactive iodine, there are a number of ways we can help. We have remembered our friend, elemental boron and the position it plays on the earth. Boron is the only mineral capable of accepting and ionizing radiation that never changes the innards or the nucleus of the cell. Spoken simply, boron can take radiation and release it without upsetting its own very delicate balance.–Boron is used extensively in the nuclear industry. Sodium borate is regularly used for standby liquid control systems, in case of emergencies. It was used in Cheronbyl in 1986 mixed with sand to prevent further radiation leakage. It was also used in 1999 in Tokaimura, Japan, to absorb the massive amounts of radiation after an accident at a plant. Currently it is being dumped on fuel rods and in surrounding waters of the Fukushima plant. Boron is widely recognized as extremely safe and can be used to capture radioactivity on our soils, gardens, orchards, etc. It also can be safely ingested by humans and animals. Boron will accept radiation and ionize it within our bodies, after which our bodies will safely excrement the boron and radioactivity.—We have begun feeding our cows and goats sodium borate at milking times, as well as adding it to free choice kelp and water troughs. In the past years we have monitored boron and other minerals in the soil and have added as necessary to bring levels up to recognized healthy levels. As a safety measure we are planning to implement a boron dosage to all of our pastures, as well as neighboring pastures. For humans, boron can safely ingested at a dosage of 4-10 mg per day. Borax, 11% boron, can be used as a tea and sprayed on your gardens, or land surrounding your home, at a rate of 10# of Borax per acre, 1#, if using elemental boron. Borax can also be ingested at 1/8 tsp to 1 litre water for women, ¼ tsp to 1 litre water for men. Fortunately, red wine and coffee are significant sources of boron, as well as non-citrus fruits, red grapes, plums, pears, apples, avocados, legumes and nuts! Boron is known to be non-carcinogenic, non-mutagenic and has been used internally to protect the astronauts in space as they leave the earth’s protective magnetic field.–Other things we can do to protect our bodies are to consume zeolites, use potassium iodine, receive plenty of glutathione, the best source of which is whey!, eat plenty of supergreens, such as kale, but including chlorella and spirulina, maintain healthy mineral levels, and eat lots of good healthy fats, including raw butter, and coconuts, which offer a fantastic layer of protection for our cells. Baking soda has been known to diminish the severity of change produced by uranium to the kidneys, which are the first to show radiation damages of uranium. Dosage is 1 tsp to 8 oz water for adults and ¼ tsp in 4 oz water for children.–According to Cheryl McCoy, Aboutclay.com, Clay acts as a magnet absorbing anything with a positive charge, ie radiation and toxicity. She suggests washing all produce which may be considered radioactive in 1 part clay to 8 parts water in a non-metallic bowl, soaking for 10 minutes, then rinse and dry as usual. Clay can be added to catchment tanks, drinking water or raw milk to isolate radioactivity, which will not be released once captured by clay. Also, the body cannot digest clay, but will rather release clay through excrement. Clay can be added to milk or drinking water at a dosage of 1 oz Clay to 1 gallon raw milk or drinking water. Either allow to settle and pour off or mix and consume clay and liquid. 1-2 oz clay can be safely consumed per day by an adult, with significant detox abilities.-In these tenuous times it is all we can do to be honestly informed of the situation at hand and act accordingly. We are doing our best to protect our soil, animals and bodies from the elevated levels of radioactivity, and hope that you will also. Our prayers and blessings are with the farmers and families closer to the source of radioactive pollution. We send them our love and hopes for a green, safe future for all on this earth.

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Chronic use of acetaminophen tied to blood cancers

 

NEW YORK— Chronic users of the painkiller acetaminophen are at a slightly increased risk for blood cancers, according to a U.S. study. But the risk remains low and it is still uncertain what role the drug plays, the study, published in the Journal of Clinical Oncology, added. Earlier work has shown that aspirin use might lower the odds of dying from colon cancer but increase the risk of bleeding ulcers, though the picture has been less clear about blood, or hematologic, cancers.”A person who is age 50 or older has about a 1 percent risk in ten years of getting one of these cancers,” said Emily White at the Fred Hutchinson Cancer Research Center in Seattle, who worked on the study.”Our study suggests that if you use acetaminophen at least four times a week for at least four years, that would increase the risk to about 2 percent.”Noting that the current study was the first large prospective one on the issue, as opposed to individual case reports, she added that there’s still no proof that acetaminophen causes cancer. The new trials also need to be confirmed before being used in any treatment decision. White and her team followed nearly 65,000 older men and women in Washington state, all free of any history of cancer, except skin cancer, at the start. At the outset, they asked participants about their use of analgesics over the previous ten years. Over about six years on average, 577 people — or less than 1 percent — developed a hematologic cancer. More than 9 percent of those, though, used high amounts of acetaminophen, compared to only 5 percent of those who didn’t get sick. After accounting for things such as age, arthritis and a family history of certain blood cancers, chronic acetaminophen users had nearly twice the risk of developing the diseases. No other analgesics, including aspirin and ibuprofen, were tried to the risk of blood cancers. White said it’s still too soon to make any recommendations based on the study, adding that none of the painkillers is free of side effect

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Free Iodine Therapeutic Application

The eruptive and ulcerative affections of secondary syphilis; but here its influence is less certain, and it will generally be found to operate most effectually with the aid of mercury; the auxiliary being, in my apprehension, the most efficient agent of the two. in iritis it is considered by some, when given in the form of iodide of potassium, as second only to mercury, if it be not equal to that medicine in efficiency.

Rheumatism, both chronic and neuralgic, sometimes yields happily to iodide of potassium. It has seemed to me to be specially efficacious in those vague rheumatic pains, resembling the affection just treated of as constituting one of the features of old cases of syphilis. I have often seen it effectual in such instances, when there was no reason to suppose that the affection was in any way connected with that disease. It may be tried in other forms of rheumatism, among the alterative remedies to which we are often driven, one after another, by the obstinacy of the complaint, and the impatience of the sufferer; and sometimes, almost unexpectedly, it will seem to do much good; but it cannot be depended on.

A case of atrophic muscular paralysis was successfully treated by Mr. F. Taylor, of Woodstock, England, with iodide of potassium, given in doses of five grains three times daily[i2] . The disease affected both the upper and lower extremities, and finally the face, and was attended with great atrophy of the muscles, but without any loss of sensibility. In about two weeks from the commencement of the treatment, the patient could sit up in bed, in a few days more could walk with the aid of sticks, and in two months was quite restored to health. {Med. T. & Gaz., July 11, 1863, p. 37.)

Chronic cutaneous eruptions are also among the complaints in which iodine is often used as an alterative. Though much less effectual in these complaints than either arsenic or mercury, it sometimes appears to be useful, and may be resorted to in connection with the other alteratives mentioned, or in cases in which they may be forbidden. But more may be expected from the topical application of iodine, in these affections, than from its internal use. It may be employed, according to varying circumstances, in the form of a bath, of a lotion, or an ointment. There are few local applications more efficacious, in chronic skin diseases, than the ointment of iodide of sulphur. I consider it second only to the tar ointment. When the affection is very general, the iodine bath may be preferred. In strictly local cases, the tincture of iodine will often be found extremely effectual, sometimes putting an immediate end to the complaint. It requires, however, to be used with caution, when the eruption is a mere symptom of a constitutional affection. Of the great use of tincture of iodine in superficial inflammation, I shall have occasion to treat in another place.

In poisoning from mercury and lead, particularly the latter, iodide of potassium is an admirable remedy, operating apparently by displacing the metal lodged in the tissues, and then causing its elimination. (See vol. i. p. 153.) Some are disposed to ascribe its efficacy in the form of rheumatism above referred to, connected often with periosteal swelling, to this mode of action; believing that the affection is a kind of mercurial disease. I cannot believe this, until I find proofs, by the discharge of the mercurial by the kidneys, or by the evidence of its peculiar influence vol. ii.-23 on the system, when liberated from its confinement, and admitted into the circulation, that mercury really did exist in the tissues. it has not been my lot to meet with this affection directly traceable to mercury; though few persons have, I presume, in this community, administered it in a larger number of cases than myself. Still, I have no doubt that there are cases of chronic mercurial poisoning, in which the iodide of potassium may be advantageously administered. (See Mercury, page 260.) The medicine has been given, with supposed advantage, in cases of acute mercurialism; and, upon theoretical grounds, it should operate not less efficiently here than in the chronic cases, by eliminating the offending cause, supposing that the whole of the mercurial used has been absorbed, or evacuated from the bowels.

In lead poisoning, it seems, from the reports made in its favour, to be among the most effectual remedies at our command. in these cases, evidence of its efficiency has been given by the appearance of lead in the urine shortly after its employment. it is applicable to the treatment alike of colica pictonum, and the more chronic poisoning exhibited in lead palsy.

Anomalous tumours and ulcers, of an obstinate character, generally offer an indication for the use of iodine. The ulcerative affection of the mouth denominated canker, and those of the surface which accompany ecthyma, rupia, lupus, etc., may often be most usefully treated with iodine, or its preparations, internally or locally, or in the two methods jointly. in that form of alveolar periostitis, which is attended with ulceration about the teeth, and their ultimate loss, it is said to have effected cures. it might even be tried in that fatal affection sometimes taken by man from horses, and usually called glanders. A well-marked case of the disease in a horse is said to have ended favourably, under the tincture of iodine given internally in large doses. it may be used in chronic enlargements of the liver, spleen, uterus, and ovary, and in anomalous tumours forming in the mesentery, with some hope of benefit. it will, in the great majority of these cases, fail to be of any service; but sometimes the swellings disappear under its use, and it deserves a trial in all cases not absolutely desperate. Here it may be used both internally, and by extensive friction over the surface of the abdomen with the ointment. Under the impression of its resolvent powers, it has been recommended in the advanced stages of pneumonia, and in the chronic forms of that disease, when the hepatized or consolidated lung is little disposed to resolution. I have used it occasionally, with doubtful advantage.

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Antioxidant activity and mechanism of action of thymol and carvacrol in two lipid systems

 

 

Nedyalka V. Yanishlievaa, *, Emma M. Marinovaa, Michael H. Gordonb and Violeta G. Ranevaa

a Institute of Organic Chemistry with Center of Phytochemistry, Bulgarian Academy of Sciences, kv. Geo Milev, Acad. G. Bontchev Str., bl. 9, 1113 Sofia, Bulgaria b Hugh Sinclair Unit of Human Nutrition, Department of Food Science and Technology, University of Reading, Whiteknights, PO Box 226, Reading RG6 6AP, UK

Received 12 December 1997; accepted 9 February 1998. Available online 25 November 1998.

 

Abstract

The autoxidation of purified triacylglycerols of lard and sunflower oil (TGL and TGSO) containing 0.02, 0.05, 0.10 and 0.20% thymol and carvacrol was studied at ambient temperature. The results obtained with the inhibited lipid systems (thymol – TGL; carvacrol – TGL; thymol – TGSO and carvacrol – TGSO) showed that thymol had the highest antioxidant effectiveness and activity during TGSO oxidation. Thymol and carvacrol participated in one side reaction during inhibited TGL oxidation, and thymol took part in two side reactions during TGSO oxidation. Carvacrol molecules did not participate in side reactions during TGSO oxidation. Thymol and carvacrol contributed to chain initiation to a higher degree during TGSO oxidation than during TGL oxidation. Thymol radicals did not participate in chain propagation during TGL and TGSO oxidation. Carvacrol radicals took part in one reaction of chain propagation in both lipid systems. In general, during autoxidation of lipids at ambient temperature, thymol is a more effective and more active antioxidant than carvacrol. Both antioxidants differ in the mechanism of their inhibiting action which depends on the character of the lipid medium. Thymol is a better antioxidant in TGSO than in TGL, whereas the activity of carvacrol in the two lipid systems does not differ significantly.

Index Terms: antioxidant activity; autooxidation; lipid oxidation; food quality; thymol; carvacrol; sunflower oil; lard

 

 

When consuming fats any fat or supplement that is fat based –you want to reduce the oxidation process as much as possible- to do this you will need antioxidants—and here is one way of increasing n antioxidant that is relatively inexpensive and can be grown by anyone—you can utilize thyme or Savoury since they both have the antioxidants required to reduce the break down of the lipids ( fats) in the system—

 

Recipe-You can either Use an essential oil by adding drops to a oil container—750 ml container ( 25 oz) adding anywhere from 3-10 drops in the oil and then shake it well or adding one drop to a tablespoon of any oil you are consuming either straight up or cooking—you can as well add this to any beverage or meat or any food to either protect against any type of pathogen or bacterial or microbial problems —when consuming these foods or fats you will receive the added protection and benefit from not only the antioxidant effect but the anti bacterial-antifungal-antiviral and antimicrobial and antioxidant properties as well.