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Amino Acid Supplement Makes Mice Live Longer

ScienceDaily (Oct. 5, 2010) — When mice are given drinking water laced with a special concoction of amino acids, they live longer than your average mouse, according to a new report in the October issue of Cell Metabolism, a Cell Press publication. The key ingredients in the supplemental mixture are so-called branched-chain amino acids, which account for 3 of the 20 amino acids (specifically leucine, isoleucine, and valine) that are the building blocks of proteins.—“This is the first demonstration that an amino acid mixture can increase survival in mice,” said Enzo Nisoli of Milan University in Italy, noting that researchers last year showed that leucine, isoleucine, and valine extend the life span of single-celled yeast.–In the new study, the researchers gave middle-aged, male mice extra branched-chain amino acids (BCAA) in their drinking water. The animals were otherwise healthy and eating standard mouse chow.–Animals that were given the extra amino acids over a period of months lived longer, with a median life span of 869 days compared to 774 days for untreated control animals, the researchers report. That’s an increase of 12 percent.—Those survival gains were accompanied by an increase in mitochondria in cardiac and skeletal muscles. Mitochondria are the cellular components responsible for powering cells. The supplement-fed mice also showed increased activity of SIRT1, a well-known longevity gene, and of the defense system that combats free radicals. They therefore showed fewer signs of oxidative damage.–The benefits of the amino acid supplements appear similar to those earlier ascribed to calorie restriction, Nisoli said.—Treated animals also showed improvements in their exercise endurance and in motor coordination, the researchers report. (It is important to note that the animals in the current study were all male, Nisoli said. They plan to test the effects in females in future studies.)–The findings in older mice suggest that the supplementary mixture may be specifically beneficial for those who are elderly or ill. “It may not be useful in young people or body builders,” who are already in good condition, he said. But it might be a useful preventive strategy, he added, emphasizing that the mice they studied “were just aged, not sick.”–Nisoli emphasized that consuming amino acid supplements is different from consuming proteins containing those amino acids. That’s because they do not have to be digested, and can enter the bloodstream immediately. “They come with no energy cost.”—He suspects that BCAA nutritional supplements may prove to be particularly helpful for people with heart failure, the muscle-wasting condition known as sarcopenia, chronic obstructive pulmonary disease, or other conditions characterized by energy defects. In fact, there are already some small studies in human to support that idea and BCAA supplements are already available for purchase in several countries, including Italy.–The challenge, Nisoli says, will be convincing clinicians that these supplements might be a benefit to their patients. He says a large clinical trial is needed, but there is little incentive for companies to do such trials for dietary supplements as opposed to drugs.

Overall, Nisoli said the new work supports a “general philosophy of a nutritional approach to disease, aging, and problems of energy status.”The researchers include Giuseppe D’Antona, Pavia University, Pavia, Italy; Maurizio Ragni, Milan University, Milan, Italy; Annalisa Cardile, Milan University, Milan, Italy; Laura Tedesco, Milan University, Milan, Italy, Brescia University, Brescia, Italy; Marta Dossena, Milan University, Milan, Italy, Brescia University, Brescia, Italy; Flavia Bruttini, Pavia University, Pavia, Italy; Francesca Caliaro, Pavia University, Pavia, Italy; Giovanni Corsetti, Brescia University, Brescia, Italy; Roberto Bottinelli, Pavia University, Pavia, Italy; Michele O. Carruba, Milan University, Milan, Italy, Brescia University, Brescia, Italy; Alessandra Valerio, Milan University, Milan, Italy, Brescia University, Brescia, Italy; and Enzo Nisoli, Milan University, Milan, Italy, Brescia University, Brescia, Italy.

Story Source–The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Cell Press, via EurekAlert!, a service of AAAS.—More info on BCAA

Branch Chain Amino Acids


ØØØThere are 3 amino acids that make a branch chain…they are Isoleucine, Leucine, and Valine.—


Isoleucine does in the body: for hemoglobin formation and stabilizes sugar, it metabolizes into muscle, and is used by the body for energy and repairing of muscle tissue. It is also used for endurance and enhances energy. Isoleucine is utilizing both fat and carbohydrates, where as vlaine specifically utilizes carbs and leucine to fats. Defiency in isoleucine is shown in muscle tremors. Oral isoleucine loading 10 grams elevated 15 times above normal, it is found that it more absorbable the the other 2 aminos. It is metabolize by either carbs or fat.


Leucine does in the body: leucine is one to promote growth hormone in the body, lowers blood sugar levels in the body, leucine stimulates insulin release, which in turn stimulates protein synthesis, and INHIBITS PROTEIN BREAKDOWN , it also is used in the REUTILIZATION OF PROTEIN in the ORGANS. Leucine metabolic pathway is solely fat.


Valine does in the body: valine is found in high levels in muscle tissue, it is a key amino in nitrogen balancing and muscle repair. It has a stimulating effect, and is used for muscle metabolism, it is also used for liver ailments. Valines metabolic route is strictly carbohydrates (utilizes carbs)10 grams of valine elevated blood levels 6 times normal, valine raised growth hormone to ten times normal., it also converts to glucose.


ùSo if you are Diabetic—Heart and Organ issues the use of these Branch Chain may assist in Stabilizing the condition and assist in the recovery from these conditions


Edible RFID Tracking Chips in Footh and choices.

Scientists push to implement edible RFID tracking chips in food

It will monitor your calorie intake, show from where your food was sourced, and even let you know when the food in your fridge is about to go bad — these are some of the enticing claims made by the developers of a new system that embeds edible radio frequency identification (RFID) chips directly into food. Its creators insist the technology will revolutionize the way humans eat for the better, but critical-thinking onlookers will recognize the ploy as just another way to track and control human behavior.—Developed by Hannes Harms from the Royal College of Art in London, the “NutriSmart” system is based on the idea that RFID wafers injected directly into food can help better track the food supply chain, further automate the supermarket shopping experience, and simplify the eating experience by programming data into food so that humans essentially do not have to think about what they are doing.—[U6]The technology makes both eating and dealing with food in general mindless, as a person simply needs to plop an RFID-embedded food item onto a special RFID-laced plate, which then tells the person all about the item and how much of it to eat.[U7] RFID ovens and microwaves also eliminate having to think about how long to cook an RFID food item — simply put it in the RFID microwave, oven, or toaster, and the machine will know exactly how long to cook the item.—As interesting and novel as this might sound, such technology is actually quite frightening when taken to its logical ends. There has been warnings that mad scientists have already developed edible RFID tags for use in pharmaceuticals. These tags, of course, can and will likely be used to monitor patients’ compliance with doctors orders, and alert authorities if a patient refuses to take certain pills as prescribed.—[U8] And if such technology also ends up in food, it is safe to assume that powerful institutions such as Drug companies and agro businesses will seek to control the food supply with it, as well as monitor the types of food people eat. In other words, if authorities one day decide that vitamin and mineral supplements are off limits, which is what is currently happening in Europe, it is plausible that RFID technology can assess illegal intake of such nutrients, and immediately send this data to the appropriate enforcement agencies.—[U9]The Drama — it is unfolding before our eyes just a little bit more every single day. And the NutriSmart system is just another piece of evidence that those in power wish to micromanage every single aspect of our lives, from the drugs we take to the foods we eat.



Elderberry juice seized at winery in Mulvane

U.S. marshals have seized elderberry juice concentrate products distributed by a Mulvane area-based company because a federal agency said the products make false claims about prevention and treatment of diseases.–The Food and Drug Administration said Friday that Wyldewood Cellars has been distributing products that are non approved and misbranded drugs. [U10]Wyldewood claims that its elderberry juice concentrate cures, treats or prevents various diseases such as AIDS, diabetes and flu, according to the FDA complaint. [U11]But John Brewer, who co-founded the business in 1994, said Wyldewood doesn’t make any such claims.–“This is a matter of the attorneys talking to each other, find out what the complaint is and we’ll fix it,” Brewer said.–Marshals came to Wyldewood’s main distribution center near Mulvane on Wednesday and moved all the elderberry juice concentrates to a back room.–“They put some stickers on it saying we can’t touch it,” Brewer said. Barry Grissom, U.S. Attorney for Kansas, said that Wyldewood was first notified in 2006 in a warning letter that its claims for the medicinal powers of elderberry juice are unproven and violate federal law.[U12] Wyldewood responded by promising to remove all such claims from its websites, the FDA said. But the FDA said it discovered during subsequent inspections that the company continues to make the same claims.–Brewer said the company did receive that warning letter and the issue was over labeling. A consultant familiar with FDA regulations was hired by Wyldewood to make changes so the label reflected that the product was being sold as a supplement. “We haven’t heard anything from (the FDA) since,” he said. “They’ve been in our facility multiple times. “It’s like, ‘C’mon guys, we changed our label, we changed everything we thought we were supposed to do.’ And then they show up and so this. ” (Supplements) seems to be one of their hot buttons these days.”

The FDA filed its complaint against the company May 27.

“Products with unapproved disease claims are dangerous because they may cause consumers to delay or avoid legitimate treatments,” [U13]Dara Corrigan, FDA’s associate commissioner for regulator affairs, said in a statement. There are no claims by the FDA that drinking the elderberry juice concentrate causes any health concerns, said Jim Cross, a spokesman for Grissom. Wyldewood has retail stores in west Wichita, Lawrence, Paxico and St. Joseph, Ill. FDA hasn’t sought to seize any of the products except for those at the facility near Mulvane, Cross said. Wyldewood produces more than 40 types of Kansas wine, according to the company’s website. Reach Rick Plumlee at 316-268-6660 or

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