B13 OROTIC ACID

B13 OROTIC ACID

Also known as:  Animal Galactose Factor;  Oro;  Orodin;  Oropur;  Orotate;  Orotonin;  Oroturic;  Orotyl;  Vitamin B13;  Whey Factor

Description

Orotic Acid is an endogenous Pyrimidine produced during the metabolism of Nucleic Acids and also obtained in small amounts in the diet.

Health Benefits of Orotic Acid

Aging & Life Extension

The Magnesium Orotate form of Orotic Acid may prevent the deposition of Lipofuscin in the body’s cells.  [more info]

Cardiovascular System

Orotic Acid may increase the strength of contraction of damaged Cardiac Muscle. 

Orotic Acid (3,000 mg of the Magnesium Orotate form per day) may alleviate Mitral Valve Prolapse. 

Conventional Medical Procedures

Orotic Acid (in the form of Potassium Orotate) may accelerate recovery from Surgery and may accelerate recovery of the Immune System following Surgery.  references

Immune System

Orotic Acid (1,000 – 2,500 mg of Calcium Orotate per day) may be useful for the treatment of Lupus Erythematosus. 

Metabolism

Orotic Acid may alleviate some cases of (chronic) Hepatitis. 

Orotic Acid (745 – 1,490 mg per day of Calcium Orotate) may facilitate weight loss in Obesity sufferers.  references

Musculoskeletal System

Orotic Acid (4,000 mg per day for six days) may alleviate Gout by reducing Uric Acid levels.  references

        Orotic Acid may facilitate Muscle Growth (this accounts for the popularity of Whey Protein supplements with bodybuilders – Whey contains a considerable quantity of Orotic Acid).  [more info]

Orotic Acid (in the form of Calcium Orotate) may be useful for the treatment of Ankylosing Spondylitis.  references

Nervous System

Orotic Acid (745 – 1,490 mg per day of Calcium Orotate) may increase Alertness.  references

        Orotic Acid (745 – 1,490 mg per day of Calcium Orotate) may improve Mood.  references

        Orotic Acid (Calcium Orotate form) may be useful for the treatment of Multiple Sclerosis.  references

Skin

Orotic Acid (300 – 1,000 mg per day of Calcium Orotate) may alleviate Psoriasis.  references

        Orotic Acid (Potassium Orotate form) may accelerate the healing of Wounds.  references

Orotic Acid may Enhance the Function of these Substances

Minerals

Orotic Acid may facilitate the transport of Minerals into the bloodstream from the digestive tract – some supplemental forms of Minerals are therefore provided in forms that are bound to Orotic Acid, in order to enhance their bioavailability.  references

Nucleic Compounds

Orotic Acid is an essential intermediate in the synthesis of Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) – this occurs as a result of its role in the synthesis of Pyrimidines.  references

–       Orotic Acid is converted within the body to form Uridine Monophosphate (UMP).

Peptides

Orotic Acid (Potassium Orotate form) may increase (reduced) Glutathione levels.  references

These Substances may Enhance the Function of Orotic Acid

Amino Acids

Orotic Acid can be synthesized within the human body from Amino Acids including Glutamine.

Enzymes

Orotate Phosphoribosyltransferase (OPRTase) is responsible for catalyzing the first step in the conversion of Orotic Acid to Uridine.  The precise mechanism involves the attachment of a Ribose + Phosphate group to Orotic Acid to form Orotidine 5′-Monophosphate (OMP).  OMP is the immediate precursor of Uridine 5′-Monophosphate (UMP).

Dietary Sources of Orotic Acid  references

(mg of Orotic Acid per 100 grams)

Dairy Products:       Milk         Whey       7 – 124

Yogurt                    

Seeds:      Orotic Acid is a component of many Seeds.

Vegetables:     Beetroot          Carrots   

Jerusalem Artichoke      

These Substances may Interfere with Orotic Acid

Amino Acids

Excessive Lysine may increase the excretion of Orotic Acid via the Urine.  references

Toxic Effects of Orotic Acid

Immune System

Excessive consumption of exogenous Orotic Acid may cause Liver Cancer.

Metabolism

Excessive consumption of exogenous Orotic Acid may damage the Liver.

Forms of Orotic Acid

Calcium Orotate (also known as Calcium Diorotate) is comprised of 20.6% Calcium bound to 79.4% Orotic Acid.

        Carnitine Orate consists of 60% L-Carnitine bound to 40% Orotic Acid.

        Copper Orotate consists of Copper bound to Orotic Acid.

        Lithium Orotate consists of Lithium bound to Orotic Acid.

Magnesium Orotate consists of 6.9% – 7.5% Magnesium bound to 92.5% – 93.1% Orotic Acid.

        Potassium Orotate consists of 20% Potassium bound to 80% Orotic Acid.

        Zinc Orotate consists of Zinc bound to Orotic Acid.

Dosage Recommendations

The usual therapeutic dosage of supplemental Orotic Acid is 50 – 100 mg per day.

        Claims relating to the use of Orotic Acid for the treatment of chronic Hepatitis have involved the daily use of 4,000 mg of the Calcium Orotate form of Orotic Acid per day for several months.

        A dosage of 4,000 mg of Orotic Acid is normally used for a maximum of six days in Gout patients.

Commercial Availability of Orotic Acid Supplements

Orotic Acid is not usually supplied as a “singular” supplement but is provided in products designed to increase the bioavailability of Minerals (as Orotates).

Mineral Orotates Products

Orotic Acid is available from health food stores and mail order supplement companies (worldwide) in the form of:

–       400 – 745 mg Calcium Orotate tablets

–       135 mg Lithium Orotate tablets (sold only in the USA)

–       200 – 775 mg Magnesium Orotate tablets

–       175 – 300 mg Potassium Orotate tablets

–       45 – 316 mg Zinc Orotate tablets (sold only in the USA)

Chemical Data

Chemical Names

1,2,3,6-tetrahydro-2,6-dioxo-4-Pyrimidinecarboxylic acid

        2,4-dioxy-6-carboxy pyrimidine

        uracil-6-carboxylic acid

        6-uracilcarboxylic acid

        6-carboxyuracil

2,6-dihydroxy-4-pyrimidinecarboxylic acid

        2,4-dioxy-6-carboxy pyrimidine

Molecular Weight

110.0

Molecular Formula

C5H4N2O4

In-Tele-Health © 2006  (from Hyperhealth Pro CD-ROM)